Ethnopharmacological relevance Licorice is a medicinal herb with a 2000-year history of
applications in traditional Chinese medicine. Isoliquiritigenin (ISL) is a bioactive chalcone …

Background Neurodegenerative diseases are a common group of neurological disorders
characterized by progressive loss of neuronal structure and function leading to cognitive …

Subarachnoid hemorrhage (SAH) is a neurological emergency characterized by
dysfunctional inflammatory response. However, no effective therapeutic options have been …

Ferroptosis is characterized by excessive accumulation of iron and lipid peroxides, which
are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an …

Rheumatoid arthritis (RA) is a chronic inflammatory condition known for its irreversible
destructive impact on the joints. Chondrocytes play a pivotal role in the production and …

Oxidative stress and neuroinflammation are two major causes leading to early brain injury
after subarachnoid hemorrhage (SAH). Nuclear factor E2-related factor 2 (Nrf2) is a critical …

Background The transcription factor NRF2 is a master redox switch that regulates the
cellular antioxidant response. However, recent advances have revealed new roles for NRF2 …

Background Several clinical and experimental studies have shown that therapeutic
strategies targeting oxidative damage are beneficial for subarachnoid hemorrhage (SAH). A …

Subarachnoid hemorrhage (SAH) is a prevalent cerebrovascular disease with significant
global mortality and morbidity rates. Despite advancements in pharmacological and surgical …

The N-heterocyclic carbene (NHC)-catalyzed enantioselective Petasis-like alkenylation of o-
hydroxycinnamaldehydes or hydroxyl-tethered α, β-unsaturated aldehydes with styryl …