The overall success of human reproduction, either spontaneously or after IVF, is highly
dependent upon maternal age. The main reasons for age-related infertility include reduced …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

STUDY QUESTION How should recurrent implantation failure (RIF) in patients undergoing
ART be defined and managed? SUMMARY ANSWER This is the first ESHRE good practice …

Objective To determine the clinical value of preimplantation genetic diagnosis for
aneuploidy screening (PGD-A) in women of advanced maternal age (AMA; between 38 and …

BACKGROUND A normal chromosomal constitution defined through PGT-A assessing all
chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo …

There is a high incidence of chromosomal abnormalities in early human embryos, whether
they are generated by natural conception or by assisted reproductive technologies (ART) …

As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …

Globally, IVF patients are routinely offered and charged for a selection of adjunct treatments
and tests or 'add-ons' that they are told may improve their chance of a live birth, despite there …

Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

Reproductive aging is characterized by a decline in oocyte quantity and quality, which is
directly associated with a decline in reproductive potential, as well as poorer reproductive …