What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?

JI Berger, AJ Billig, W Sedley, S Kumar… - Human brain …, 2024 - Wiley Online Library
The hippocampus and parahippocampal gyrus have been implicated as part of a tinnitus
network by a number of studies. These structures are usually considered in the context of a …

[HTML][HTML] A Systematic Review on the Genetic Contribution to Tinnitus

P Perez-Carpena, JA Lopez-Escamez… - Journal of the …, 2024 - Springer
Purpose To assess the available evidence to support a genetic contribution and define the
role of common and rare variants in tinnitus. Methods After a systematic search and quality …

[HTML][HTML] Genetic architecture distinguishes tinnitus from hearing loss

RE Clifford, AX Maihofer, C Chatzinakos… - Nature …, 2024 - nature.com
Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical
specialties. Previous GWAS indicated high genetic correlations between tinnitus and …

[HTML][HTML] Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically …

SM Díaz-Rodríguez, MJ Herrero-Turrión… - Frontiers in Molecular …, 2024 - frontiersin.org
Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven
neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy …

[HTML][HTML] Rare deletions or large duplications contribute to genetic variation in patients with severe tinnitus and Meniere disease

A Escalera-Balsera, AM Parra-Perez… - Genes, 2023 - mdpi.com
Meniere disease (MD) is a debilitating disorder of the inner ear defined by sensorineural
hearing loss (SNHL) associated with episodes of vertigo and tinnitus. Severe tinnitus, which …

[HTML][HTML] Identifying Health-Related Conditions Associated with Tinnitus in Young Adults

IS Bhatt, NJ Washnik, S Kingsbury, AK Deshpande… - Audiology …, 2023 - mdpi.com
Objective: The present study investigated the epidemic of tinnitus in college-aged young
adults. Our first objective was to identify health conditions associated with tinnitus in young …

Tinnitus Mechanisms and the Need for an Objective Electrophysiological Tinnitus Test. A Review.

E Fabrizio-Stover, DL Oliver, AL Burghard - Hearing Research, 2024 - Elsevier
Tinnitus, the perception of sound with no external auditory stimulus, is a complex,
multifaceted, and potentially devastating disorder. Despite recent advances in our …

Treatment outcomes in tinnitus patients are associated with brain functional network: evidence from connectome gradient and gene expression analysis

N Wu, M Xu, C Liu, Q Chen, JH Gao, Z Wang, H Lv - Neuroscience, 2024 - Elsevier
The neuroimaging mechanisms underlying differences in the outcomes of sound therapy for
tinnitus patients remain unclear. We hypothesize that abnormal hierarchical architecture is …

[HTML][HTML] Mice prone to tinnitus after acoustic trauma show increased pre-exposure sensitivity to background noise

N Rybalko, Š Suchánková, Z Bureš… - Frontiers in Behavioral …, 2023 - frontiersin.org
Noise-induced tinnitus is generally associated with hearing impairment caused by traumatic
acoustic overexposure. Previous studies in laboratory animals and human subjects …

[HTML][HTML] Development, Insults and Predisposing Factors of the Brain's Predictive Coding System to Chronic Perceptual Disorders—A Life-Course Examination

A Yasoda-Mohan, S Vanneste - Brain Sciences, 2024 - mdpi.com
The predictive coding theory is currently widely accepted as the theoretical basis of
perception and chronic perceptual disorders are explained as the maladaptive …