G-Quadruplexes in the Regulation of Viral Gene Expressions and Their Impacts on Controlling Infection
G-quadruplexes (G4s) are noncanonical nucleic acid structures that play significant roles in
regulating various biological processes, including replication, transcription, translation, and …
regulating various biological processes, including replication, transcription, translation, and …
A G-quadruplex motif at the 3′ end of sgRNAs improves CRISPR–Cas9 based genome editing efficiency
Originating as a component of prokaryotic adaptive immunity, the type II CRISPR/Cas9
system has been repurposed for targeted genome editing in various organisms. Although …
system has been repurposed for targeted genome editing in various organisms. Although …
RNA G-quadruplexes as key motifs of the transcriptome
G-Quadruplexes are non-canonical secondary structures that can be adopted under
physiological conditions by guanine-rich DNA and RNA molecules. They have been …
physiological conditions by guanine-rich DNA and RNA molecules. They have been …
Control of the polyamine biosynthesis pathway by G2-quadruplexes
G-quadruplexes are naturally-occurring structures found in RNAs and DNAs. Regular RNA
G-quadruplexes are highly stable due to stacked planar arrangements connected by short …
G-quadruplexes are highly stable due to stacked planar arrangements connected by short …
Profusion of G-quadruplexes on both subunits of metazoan ribosomes
S Mestre-Fos, PI Penev, JC Richards, WL Dean… - PLoS …, 2019 - journals.plos.org
Mammalian and bird ribosomes are nearly twice the mass of prokaryotic ribosomes in part
because of their extraordinarily long rRNA tentacles. Human rRNA tentacles are not fully …
because of their extraordinarily long rRNA tentacles. Human rRNA tentacles are not fully …
Stability of two-quartet G-quadruplexes and their dimers in atomistic simulations
B Islam, P Stadlbauer, M Vorlickova… - Journal of Chemical …, 2020 - ACS Publications
G-quadruplexes (GQs) are four-stranded noncanonical DNA and RNA architectures that can
be formed by guanine-rich sequences. The stability of GQs increases with the number of G …
be formed by guanine-rich sequences. The stability of GQs increases with the number of G …
Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches
SG Rouleau, JD Beaudoin, M Bisaillon… - Nucleic acids …, 2015 - academic.oup.com
Abstract G-quadruplexes (G4) are intricate RNA structures found throughout the
transcriptome. Because they are associated with a variety of biological cellular mechanisms …
transcriptome. Because they are associated with a variety of biological cellular mechanisms …
G-Quadruplex-enabling sequence within the human tyrosine hydroxylase promoter differentially regulates transcription
G-Quadruplexes (GQs) found within the promoter regions of genes are known to mostly act
as repressors of transcription. Here we report a guanosine (G)-rich segment in the 3 …
as repressors of transcription. Here we report a guanosine (G)-rich segment in the 3 …
Rationally induced RNA: DNA G-quadruplex structures elicit an anticancer effect by inhibiting endogenous eIF-4E expression
D Bhattacharyya, K Nguyen, S Basu - Biochemistry, 2014 - ACS Publications
RNA G-quadruplex (GQ) structures act as regulators of a diverse array of cellular processes
including translation, pre-mRNA processing, and mRNA targeting. We report here a strategy …
including translation, pre-mRNA processing, and mRNA targeting. We report here a strategy …
A Branched SELEX Approach Identifies RNA Aptamers That Bind Distinct HIV-1 Capsid Structural Components
PR Gruenke, MD Mayer, R Aneja… - ACS Infectious …, 2024 - ACS Publications
The HIV-1 capsid protein (CA) assumes distinct structural forms during replication, each
presenting unique, solvent-accessible surfaces that facilitate multifaceted functions and host …
presenting unique, solvent-accessible surfaces that facilitate multifaceted functions and host …