[HTML][HTML] Genome-wide regulatory dynamics of G-quadruplexes in human malaria parasite Plasmodium falciparum
The AT-rich genome of P. falciparum has uniquely localized G-rich stretches that have
propensity to form G-quadruplexes. However, their global occurrence and potential …
propensity to form G-quadruplexes. However, their global occurrence and potential …
Stable G-quadruplex enabling sequences are selected against by the context-dependent codon bias
GM Arachchilage, MH Arachchilage, A Venkataraman… - Gene, 2019 - Elsevier
The distributions of secondary structural elements appear to differ between coding regions
(CDS) of mRNAs compared to the untranslated regions (UTRs), presumably as a …
(CDS) of mRNAs compared to the untranslated regions (UTRs), presumably as a …
Role of G-quadruplex located at 5 end of mRNAs
P Agarwala, S Pandey, S Maiti - … et Biophysica Acta (BBA)-General Subjects, 2014 - Elsevier
Background Secondary structures in 5′ UTR of mRNAs play a critical role in regulating
protein synthesis. Though studies have indicated the role of secondary structure G …
protein synthesis. Though studies have indicated the role of secondary structure G …
G-quadruplexes in genomes of viruses infecting eukaryotes or prokaryotes are under different selection pressures from hosts
G-quadruplexes in viral genomes can be applied as the targets of antiviral therapies, which
has attracted wide interest. However, it is still not clear whether the pervasive number of …
has attracted wide interest. However, it is still not clear whether the pervasive number of …
RNA G-quadruplexes inhibit translation of the PE/PPE transcripts in Mycobacterium tuberculosis
The role of RNA G-quadruplexes (rG4s) in bacteria remains poorly understood. High G-
quadruplex densities have been linked to organismal stress. Here we investigate rG4s in …
quadruplex densities have been linked to organismal stress. Here we investigate rG4s in …
Loop nucleobases-dependent folding of G-quadruplex in normal and cancer cell-mimicking KCl microenvironments
In this study, the folding of G-quadruplex (G4) from the telomeric DNA sequences having
loop nucleobases of different chemical natures, numbers, and arrangements in 10 mM and …
loop nucleobases of different chemical natures, numbers, and arrangements in 10 mM and …
Plant thermosensors
J Li, Y Song - Plant Science, 2024 - Elsevier
Plants dynamically regulate their genes expression and physiological outputs to adapt to
changing temperatures. The underlying molecular mechanisms have been extensively …
changing temperatures. The underlying molecular mechanisms have been extensively …
Biophysical characterization of G-quadruplex recognition in the PITX1 mRNA by the specificity domain of the helicase RHAU
Nucleic acids rich in guanine are able to fold into unique structures known as G-
quadruplexes. G-quadruplexes consist of four tracts of guanylates arranged in parallel or …
quadruplexes. G-quadruplexes consist of four tracts of guanylates arranged in parallel or …
Structural transitions in poly (A), poly (C), poly (U), and poly (G) and their possible biological roles
MI Zarudnaya, IM Kolomiets… - Journal of …, 2019 - Taylor & Francis
The homopolynucleotide (homo-oligonucleotide) tracts function as regulatory elements at
various stages of mRNAs life cycle. Numerous cellular proteins specifically bind to these …
various stages of mRNAs life cycle. Numerous cellular proteins specifically bind to these …
Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents
Angiogenesis is important in tumorigenesis and tumor progression. Human vascular
endothelial growth factor (hVEGF) is an angiogenic growth factor that plays a crucial role in …
endothelial growth factor (hVEGF) is an angiogenic growth factor that plays a crucial role in …