RNA G-quadruplex: the new potential targets for therapy
Roles of RNA on transcriptional and post-transcriptional regulations have raised more
attention since the new era of genomics. One of the secondary structures of RNA, the RNA …
attention since the new era of genomics. One of the secondary structures of RNA, the RNA …
Structure validation of G‐rich RNAs in noncoding regions of the human genome
O Binas, I Bessi, H Schwalbe - ChemBioChem, 2020 - Wiley Online Library
We present the rapid biophysical characterization of six previously reported putative G‐
quadruplex‐forming RNAs from the 5′‐untranslated region (5′‐UTR) of silvestrol …
quadruplex‐forming RNAs from the 5′‐untranslated region (5′‐UTR) of silvestrol …
Tetraphenylethene Derivatives Modulate the RNA Hairpin‐G‐Quadruplex Conformational Equilibria in Proto‐oncogenes
P Gupta, D Ojha, DN Nadimetla, SV Bhosale… - …, 2022 - Wiley Online Library
RNA G‐quadruplex (GQs) sequences in 5′‐UTRs of certain proto‐oncogenes co‐localize
with hairpin (Hp) forming sequences resulting in intramolecular Hp‐GQ conformational …
with hairpin (Hp) forming sequences resulting in intramolecular Hp‐GQ conformational …
Human telomeric RNA G-quadruplex response to point mutation in the G-quartets
P Agarwala, S Kumar, S Pandey… - The Journal of Physical …, 2015 - ACS Publications
Many putative G-quadruplex forming sequences have been predicted to exist in the human
genome and transcriptome. As these sequences are subject to point mutations or SNPs …
genome and transcriptome. As these sequences are subject to point mutations or SNPs …
High-Pressure Single-Molecule Studies on Non-canonical Nucleic Acids and Their Interactions
SK Mukherjee, JM Knop, R Winter - … of Chemical Biology of Nucleic Acids, 2022 - Springer
High hydrostatic pressure affects the structure, dynamics, and the stability of biomolecular
systems. Therefore, in order to describe the entire energy and conformational landscape …
systems. Therefore, in order to describe the entire energy and conformational landscape …
Tracking Topological and Electronic Effects on the Folding and Stability of Guanine-Deficient RNA G-Quadruplexes, Engineered with a New Computational Tool for …
YB Göç, J Poziemski, W Smolińska, D Suwała… - International Journal of …, 2022 - mdpi.com
The initial aim of this work was to elucidate the mutual influence of different single-stranded
segments (loops and caps) on the thermodynamic stability of RNA G-quadruplexes. To this …
segments (loops and caps) on the thermodynamic stability of RNA G-quadruplexes. To this …
Differentiation SELEX approach identifies RNA aptamers with different specificities for HIV-1 capsid assembly forms
The HIV-1 capsid protein (CA) assumes distinct assembly forms during replication, each
presenting unique, solvent-accessible surfaces that facilitate multifaceted functions and host …
presenting unique, solvent-accessible surfaces that facilitate multifaceted functions and host …
Structure and Folding Patterns of RNA G-Quadruplexes
G-quadruplexes are four-stranded nucleic acid structures, the bases of which are linked
through Hoogsteen hydrogen bonding. RNA G-quadruplex is shown to take part in a wide …
through Hoogsteen hydrogen bonding. RNA G-quadruplex is shown to take part in a wide …
Kinetics measurements of G-quadruplex binding and unfolding by helicases
B Chang-Gu, S Venkatesan, R Russell - Methods, 2022 - Elsevier
G-quadruplex structures (G4s) form readily in DNA and RNA and play diverse roles in gene
expression and other processes, and their inappropriate formation and stabilization are …
expression and other processes, and their inappropriate formation and stabilization are …
Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with CANVAS
K Kudo, K Hori, S Asamitsu, K Maeda, Y Aida… - bioRxiv, 2023 - biorxiv.org
Short tandem repeats are highly unstable, depending on repeat length, and the expansion
of the repeat length in the human genome is responsible for repeat expansion disorders …
of the repeat length in the human genome is responsible for repeat expansion disorders …