Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases
V Ivasiv, C Albertini, AE Gonçalves… - Current Topics in …, 2019 - ingentaconnect.com
Molecular hybridization is a well-exploited medicinal chemistry strategy that aims to combine
two molecules (or parts of them) in a new, single chemical entity. Recently, it has been …
two molecules (or parts of them) in a new, single chemical entity. Recently, it has been …
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease
Q Li, S He, Y Chen, F Feng, W Qu, H Sun - European journal of medicinal …, 2018 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in elderly
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …
Sustainable drug discovery of multi-target-directed ligands for Alzheimer's disease
M Rossi, M Freschi… - Journal of medicinal …, 2021 - ACS Publications
The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …
[HTML][HTML] Quinones as neuroprotective agents
Á Cores, N Carmona-Zafra, J Clerigué, M Villacampa… - Antioxidants, 2023 - mdpi.com
Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology
C Albertini, A Salerno… - Medicinal Research …, 2021 - Wiley Online Library
The continued drug discovery failures in complex neurodegenerative diseases, including
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …
Recent advances of quinones as a privileged structure in drug discovery
L Zhang, G Zhang, S Xu, Y Song - European Journal of Medicinal Chemistry, 2021 - Elsevier
Privileged structures are conductive to discover novel bioactive substances because they
can bind to multiple targets with high affinity. Quinones are considered to be a privileged …
can bind to multiple targets with high affinity. Quinones are considered to be a privileged …
Target enzyme in Alzheimer's disease: Acetylcholinesterase inhibitors
M Saxena, R Dubey - Current topics in medicinal chemistry, 2019 - ingentaconnect.com
Alzheimer's Disease (AD), affecting a large population worldwide is characterized by the
loss of memory and learning ability in the old population. The enzyme Acetylcholinesterase …
loss of memory and learning ability in the old population. The enzyme Acetylcholinesterase …
Alzheimer's disease and language impairments: social intervention and medical treatment
B Klimova, P Maresova, M Valis, J Hort… - Clinical interventions in …, 2015 - Taylor & Francis
Communication is very important for people to be successfully integrated into social
environment and make and maintain relationship. Particularly, language difficulties lead to …
environment and make and maintain relationship. Particularly, language difficulties lead to …