Recent advances in ADAM17 research: a promising target for cancer and inflammation

ML Moss, D Minond - Mediators of inflammation, 2017 - Wiley Online Library
Since its discovery, ADAM17, also known as TNFα converting enzyme or TACE, is now
known to process over 80 different substrates. Many of these substrates are mediators of …

Serum suPAR and syndecan-4 levels predict severity of community-acquired pneumonia: a prospective, multi-centre study

Q Luo, P Ning, Y Zheng, Y Shang, B Zhou, Z Gao - Critical care, 2018 - Springer
Background Community-acquired pneumonia (CAP) is a major cause of death worldwide
and occurs with variable severity. There are few studies focused on the expression of …

[HTML][HTML] Syndecan-4 is the key proteoglycan involved in mediating sepsis-associated lung injury

Z Zhu, X Ling, H Zhou, J Xie - Heliyon, 2023 - cell.com
Vascular endothelial cell dysfunction involving syndecan (SDC) proteoglycans contributes to
acute sepsis-associated lung injury (ALI), but the exact SDC isoform involved is unclear. We …

Syndecan-4 inhibits the development of pulmonary fibrosis by attenuating TGF-β signaling

Y Tanino, X Wang, T Nikaido, K Misa, Y Sato… - International journal of …, 2019 - mdpi.com
Syndecan-4 is a transmembrane heparan sulfate proteoglycan expressed in a variety of
cells, and its heparan sulfate glycosaminoglycan side chains bind to several proteins …

Syndecan 4 contributes to osteoclast differentiation induced by RANKL through enhancing autophagy

J Li, Z Sun, Y Lin, Y Yan, H Yan, B Jing… - International …, 2021 - Elsevier
Periodontitis is a common chronic disease. Osteoclast differentiation contributes to alveolar
bone resorption which is a distinct phenomenon during periodontitis. Syndecan 4 (SDC4), a …

[PDF][PDF] 七氟醚联合右美托咪定对老年食管癌根治术患者应激反应, 细胞免疫功能和认知功能的影响

邓莉, 李爱梅, 姜巧巧, 杨欢, 陈思宇 - 现代生物医学进展, 2023 - biomed.cnjournals.com
摘要目的: 探讨右美托咪定, 七氟醚复合麻醉在老年食管癌根治术患者中的应用价值,
并观察患者细胞免疫功能, 应激反应, 认知功能的变化情况. 方法: 纳入我院2021 年1 月~ 2022 …

Baseline serum syndecan-4 predicts prognosis after the onset of acute exacerbation of idiopathic interstitial pneumonia

Y Sato, Y Tanino, X Wang, T Nikaido, S Sato, K Misa… - PLoS …, 2017 - journals.plos.org
Background Patients with idiopathic interstitial pneumonia can experience acute respiratory
worsening, also known as acute exacerbation, with a large deterioration on prognosis. The …

Circulating syndecan-1 as a novel biomarker relates to lung function, systemic inflammation, and exacerbation in COPD

D Li, Y Wu, S Guo, J Qin, M Feng, Y An… - … Journal of Chronic …, 2019 - Taylor & Francis
Introduction Patients with COPD often show increased systemic inflammation which is
associated with lower functional status, greater exacerbation risk, and worse clinical …

Effects of heparan sulfate proteoglycan syndecan-4 on the insulin secretory response in a mouse pancreatic β-cell line, MIN6

I Takahashi, S Yamada, K Nata - Molecular and Cellular Endocrinology, 2018 - Elsevier
Heparan sulfate proteoglycans (HSPGs) comprise a core protein to which extracellular
glycosaminoglycan chains are attached. Syndecan-4, one of the major HS-containing core …

[HTML][HTML] MiR-629-5p May Serve as a Biomarker for Pediatric Acute Respiratory Distress Syndrome and Can Regulate the Inflammatory Response

C Zhang, Y Ji, Q Wang, L Ruan - Pediatrics & Neonatology, 2024 - Elsevier
Abstract Objective Circulating microRNAs (miRNAs) are associated with pediatric acute
respiratory distress syndromes (PARDS). This study analyzed the clinical significance and …