More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and
adaptive immune systems, mediating inflammation in response to a wide range of stimuli …

The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

The three-signal paradigm tries to capture how the innate immune system instructs adaptive
immune responses in three well-defined actions:(1) presentation of antigenic peptides in the …

Summary The interleukin (IL)‐1 family of cytokines is currently comprised of 11 members
that have pleiotropic functions in inflammation and cancer. IL‐1α and IL‐1β were the first …

NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …

Abstract Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan
members of the IL-1 ligand family and IL-1 receptor family, respectively. Here we …

Review on the ability of different TLR agonists to orchestrate antitumor immune responses,
or promote tumor growth, underscoring the impact of choosing among TLR agonists when …

The role of inflammation in atherosclerosis has been recognized several decades ago and
existing treatments provide benefits in part through non-specific anti-inflammatory actions …

Myeloid differentiation primary response protein 88 (MyD88) is a ubiquitously expressed
cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and …