Spinal cord repair: advances in biology and technology
G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …
Advances in clinical management have decreased morbidity and improved outcomes, but …
The corticospinal tract: Evolution, development, and human disorders
Q Welniarz, I Dusart, E Roze - Developmental neurobiology, 2017 - Wiley Online Library
The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …
Injured adult neurons regress to an embryonic transcriptional growth state
Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the robust regeneration
of corticospinal axons and restore forelimb function after spinal cord injury; however, the …
of corticospinal axons and restore forelimb function after spinal cord injury; however, the …
[HTML][HTML] Motor recovery after spinal cord injury enhanced by strengthening corticospinal synaptic transmission
The corticospinal tract is an important target for motor recovery after spinal cord injury (SCI)
in animals and humans [1–5]. Voluntary motor output depends on the efficacy of synapses …
in animals and humans [1–5]. Voluntary motor output depends on the efficacy of synapses …
Reticulospinal contributions to gross hand function after human spinal cord injury
Multiple descending motor pathways likely contribute to the recovery of hand motor function
following spinal cord injury (SCI). Reticulospinal neurons project to spinal motor neurons …
following spinal cord injury (SCI). Reticulospinal neurons project to spinal motor neurons …
Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates
L Friedli, ES Rosenzweig, Q Barraud… - Science translational …, 2015 - science.org
Experimental and clinical studies suggest that primate species exhibit greater recovery after
lateralized compared to symmetrical spinal cord injuries. Although this observation has …
lateralized compared to symmetrical spinal cord injuries. Although this observation has …
[HTML][HTML] Differences in neuroplasticity after spinal cord injury in varying animal models and humans
ME Filipp, BJ Travis, SS Henry… - Neural regeneration …, 2019 - journals.lww.com
Rats have been the primary model to study the process and underlying mechanisms of
recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can …
recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can …
human intracortical recording and neural decoding for brain–computer interfaces
DM Brandman, SS Cash… - IEEE Transactions on …, 2017 - ieeexplore.ieee.org
Brain-computer interfaces (BCIs) use neural information recorded from the brain for the
voluntary control of external devices. The development of BCI systems has largely focused …
voluntary control of external devices. The development of BCI systems has largely focused …
Re-establishment of cortical motor output maps and spontaneous functional recovery via spared dorsolaterally projecting corticospinal neurons after dorsal column …
Motor cortical plasticity contributes to spontaneous recovery after incomplete spinal cord
injury (SCI), but the pathways underlying this remain poorly understood. We performed …
injury (SCI), but the pathways underlying this remain poorly understood. We performed …
Multisite Hebbian plasticity restores function in humans with spinal cord injury
Objective Spinal cord injury (SCI) damages synaptic connections between corticospinal
axons and motoneurons of many muscles, resulting in devastating paralysis. We …
axons and motoneurons of many muscles, resulting in devastating paralysis. We …