Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …

Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the robust regeneration
of corticospinal axons and restore forelimb function after spinal cord injury; however, the …

The corticospinal tract is an important target for motor recovery after spinal cord injury (SCI)
in animals and humans [1–5]. Voluntary motor output depends on the efficacy of synapses …

Multiple descending motor pathways likely contribute to the recovery of hand motor function
following spinal cord injury (SCI). Reticulospinal neurons project to spinal motor neurons …

Experimental and clinical studies suggest that primate species exhibit greater recovery after
lateralized compared to symmetrical spinal cord injuries. Although this observation has …

Rats have been the primary model to study the process and underlying mechanisms of
recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can …

Brain-computer interfaces (BCIs) use neural information recorded from the brain for the
voluntary control of external devices. The development of BCI systems has largely focused …

Motor cortical plasticity contributes to spontaneous recovery after incomplete spinal cord
injury (SCI), but the pathways underlying this remain poorly understood. We performed …

Objective Spinal cord injury (SCI) damages synaptic connections between corticospinal
axons and motoneurons of many muscles, resulting in devastating paralysis. We …