Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic
strategies have been developed for various cancers, including chemotherapy, radiotherapy …

Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …

Tumors are supported by cancer-associated fibroblasts (CAFs). CAFs are heterogeneous
and carry out distinct cancer-associated functions. Understanding the full repertoire of CAFs …

Despite the increasing interest in targeting stromal elements of the tumor microenvironment,
we still face tremendous challenges in developing adequate therapeutics to modify the …

Cancer stem-like cells (CSC) play pivotal roles in both chemoresistance and recurrence of
many cancer types, including urothelial bladder cancer (UBC). In addition to intrinsic …

Increasing lines of evidence show that the malignant behavior of cancer is not exclusively
attributable to cancer cells but also radically influenced by cancerous stroma activity and …

Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …

Abstract Background and Aims We previously demonstrated that cancer‐associated
fibroblasts (CAFs) promote tumor growth through recruitment of myeloid‐derived suppressor …

Cancer‐associated fibroblasts (CAF) are orchestrators of the pancreatic ductal
adenocarcinoma (PDAC) microenvironment. Stromal heterogeneity may explain differential …

Abstract In tumors, Cancer-Associated Fibroblasts (CAFs) constitute the most prominent
component of the tumor microenvironment (TME). CAFs are heterogeneous and composed …