Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …

Gametogenesis is one of the most extreme cellular differentiation processes that takes place
in Drosophila male and female germlines. This process begins at the germline stem cell …

Stem cells possess the capacity to generate two cells of distinct fate upon division: one cell
retaining stem cell identity and the other cell destined to differentiate. These cell fates are …

The Toll signaling pathway was initially identified for its involvement in the control of early
embryogenesis. It was later shown to be also part of a major innate immune pathway …

Adult stem cells continuously undergo self-renewal and generate differentiated cells. In the
Drosophila ovary, two separate niches control germ line stem cell (GSC) self-renewal and …

Cadmium (chemical symbol, Cd) is an extremely common pollutant that poses a toxicity
threat to organisms. Therefore, we tested Drosophila melanogaster fecundity, Cd …

Stem cells reside in a niche, a local environment whose cellular and molecular complexity is
still being elucidated. In Drosophila ovaries, germline stem cells depend on cap cells for self …

Germ cell development involves major reprogramming of the epigenome to prime the zygote
for totipotency. Histone 3 lysine 4 (H3K4) methylations are universal epigenetic marks …

Wnt signaling is a conserved regulator of stem cell behaviors, and the Drosophila
germarium has been an important model tissue for the study of stem cell maintenance …

Stem cell niches provide localized signaling molecules to promote stem cell fate and to
suppress differentiation. The Drosophila melanogaster ovarian niche is established by …