The vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor
(VEGFR) axis is indispensable in the process of angiogenesis and has been implicated as a …

RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Alternative splicing affects more than 95% of multi-exon genes in the human genome. These
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …

Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …

The loss of the tail is among the most notable anatomical changes to have occurred along
the evolutionary lineage leading to humans and to the 'anthropomorphous apes',–, with a …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Abstract Background N6‐methyladenosine (m6A), the most prevalent internal mRNA
modification in eukaryotes, is added by m6A methyltransferases, removed by m6A …

Efficient targeted control of splicing is a major goal of functional genomics and therapeutic
applications. Guide (g) RNA-directed, deactivated (d) Cas CRISPR enzymes fused to …

Disruption of alternative splicing frequently causes or contributes to human diseases and
disorders. Consequently, there is a need for efficient and sensitive reporter assays capable …