Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

Microglia are critical nervous system‐specific immune cells serving as tissue‐resident
macrophages influencing brain development, maintenance of the neural environment …

Accumulation of pathological tau protein is a major hallmark of Alzheimer's disease. Tau
protein spreads from the entorhinal cortex to the hippocampal region early in the disease …

Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

Microglia have critical roles in neural development, homeostasis and neuroinflammation
and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration …

Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …

Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …

Major depressive disorder (MDD) is a common emotional cognitive disorder that seriously
affects people's physical and mental health and their quality of life. Due to its clinical and …

Parkinson's disease (PD) is a chronic and progressive disorder characterized
neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular …

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
at the post-transcriptional level and that play an important role in many cellular processes …