High-Altitude Travel with Medical Problems Travel to high altitude is increasing. The authors
discuss physiological changes at high altitude, pretravel evaluation for common medical …

At any point 1–5 days following ascent to altitudes≥ 2500 m, individuals are at risk of
developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome …

Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic
diseases in neonates, infants, and older children and contributes to significant morbidity and …

Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that is intrinsic to
the pulmonary vasculature. Intrapulmonary arteries constrict in response to alveolar hypoxia …

High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Key Clinical Points Acute High-Altitude Illnesses Acute high-altitude illnesses occur in
persons who are not acclimatized during the first days at an altitude of 2500 m or higher …

The term “high-altitude illness” is used to describe the cerebral and pulmonary syndromes
that can develop in unacclimatized persons shortly after ascent to high altitude. Acute …

Cellular hypoxia is the common final pathway of brain injury that occurs not just after
asphyxia, but also when cerebral perfusion is impaired directly (eg, embolic stroke) or …

High-altitude illness is the collective term for acute mountain sickness (AMS), high-altitude
cerebral oedema (HACE), and high-altitude pulmonary oedema (HAPE). The …