[HTML][HTML] In vitro growth and maturation of primordial follicles and immature oocytes

EE Telfer, CY Andersen - Fertility and Sterility, 2021 - Elsevier
Cryopreservation of ovarian tissue to preserve the fertility of girls and young women at high
risk of sterility is now widely practiced. Pieces of cryopreserved ovarian cortex can be …

[HTML][HTML] Role of mTOR signaling in female reproduction

Z Guo, Q Yu - Frontiers in endocrinology, 2019 - frontiersin.org
Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase of the
phosphatidylinositol kinase-related kinase family that regulates cell growth, metabolism, and …

[HTML][HTML] Human Follicle in vitro Culture Including Activation, Growth, and Maturation: A Review of Research Progress

Q Yang, L Zhu, L Jin - Frontiers in endocrinology, 2020 - frontiersin.org
Fertility preservation has received unprecedented attention nowadays. In addition to
cryopreservation and re-implantation of embryos, oocytes, and ovarian tissue pieces, in vitro …

Human organoid systems in modeling reproductive tissue development, function, and disease

S Haider, AG Beristain - Human Reproduction, 2023 - academic.oup.com
Research focused on human reproductive biology has primarily relied upon clinical samples
affording mainly descriptive studies with limited implementation of functional or mechanistic …

[HTML][HTML] Dynamic in vitro culture of bovine and human ovarian tissue enhances follicle progression and health

V Barbato, V Genovese, V De Gregorio, M Di Nardo… - Scientific Reports, 2023 - nature.com
In vitro ovarian cortical tissue culture, followed by culture of isolated secondary follicles, is a
promising future option for production of mature oocytes. Although efforts have been made …

Micromechanical characterizations and viscoelastic modeling reveal elastic and viscoelastic heterogeneities in ovarian tissue and the significant viscoelastic …

S Stewart, W Ou, H Aranda-Espinoza, SO Rahaman… - Acta Biomaterialia, 2023 - Elsevier
Ovarian follicles develop in a highly regulated mechanical microenvironment and
disruptions to the microenvironment may cause infertility. However, the viscoelastic …

DNA methylation and mRNA expression of imprinted genes in blastocysts derived from an improved in vitro maturation method for oocytes from small antral follicles in …

MD Saenz-de-Juano, E Ivanova, S Romero… - Human …, 2019 - academic.oup.com
Abstract STUDY QUESTION Does imprinted DNA methylation or imprinted gene expression
differ between human blastocysts from conventional ovarian stimulation (COS) and an …

First evidence of the protective role of melatonin in counteracting cadmium toxicity in the rat ovary via the mTOR pathway

S Kechiche, M Venditti, L Knani, K Jabłońska… - Environmental …, 2021 - Elsevier
Herein, the first evidence of the ability of melatonin (MLT) to counteract cadmium (Cd) toxic
effects on the rat ovary is reported. Cd treatment, enhancing oxidative stress, provoked clear …

The new biocompatible material for mouse ovarian follicle development in three-dimensional in vitro culture systems

EJ Kim, C Yang, J Lee, HW Youm, JR Lee, CS Suh… - Theriogenology, 2020 - Elsevier
To establish a protocol of optimized three-dimensional (3D) culture of ovarian follicles,
various biomaterials have been investigated with regard to their properties and functions on …

[HTML][HTML] Progress and challenges in developing organoids in farm animal species for the study of reproduction and their applications to reproductive biotechnologies

G Bourdon, V Cadoret, G Charpigny… - Veterinary …, 2021 - Springer
Within the past decades, major progress has been accomplished in isolating
germ/stem/pluripotent cells, in refining culture medium and conditions and in establishing 3 …