Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound

S Schoen Jr, MS Kilinc, H Lee, Y Guo… - Advanced drug delivery …, 2022 - Elsevier
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …

Ultrasound contrast imaging: Fundamentals and emerging technology

H Yusefi, B Helfield - Frontiers in Physics, 2022 - frontiersin.org
The development of microbubble contrast agents has broadened the scope of medical
ultrasound imaging. Along with dedicated imaging techniques, these agents provide …

Probing the pressure dependence of sound speed and attenuation in bubbly media: Experimental observations, a theoretical model and numerical calculations

AJ Sojahrood, Q Li, H Haghi, R Karshafian… - Ultrasonics …, 2023 - Elsevier
The problem of attenuation and sound speed of bubbly media has remained partially
unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation …

Nonlinear dynamics of acoustic bubbles excited by their pressure-dependent subharmonic resonance frequency: influence of the pressure amplitude, frequency …

AJ Sojahrood, R Earl, H Haghi, Q Li, TM Porter… - Nonlinear …, 2021 - Springer
Nonlinear behavior of bubbles, and most importantly 1 2 1 2-order subharmonics (SH), are
used to increase the contrast-to-tissue ratio (CTR) in diagnostic ultrasound (US) and to …

Toward precisely controllable acoustic response of shell-stabilized nanobubbles: High yield and narrow dispersity

A Jafari Sojahrood, AC de Leon, R Lee, M Cooley… - ACS …, 2021 - ACS Publications
Understanding the pressure dependence of the nonlinear behavior of ultrasonically excited
phospholipid-stabilized nanobubbles (NBs) is important for optimizing ultrasound exposure …

A review of phospholipid encapsulated ultrasound contrast agent microbubble physics

B Helfield - Ultrasound in medicine & biology, 2019 - Elsevier
Ultrasound contrast agent microbubbles have expanded the utility of biomedical ultrasound
from anatomic imaging to the assessment of microvascular blood flow characteristics and …

Targeted microbubbles for drug, gene, and cell delivery in therapy and immunotherapy

JA Navarro-Becerra, MA Borden - Pharmaceutics, 2023 - mdpi.com
Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically
stabilized by a phospholipid monolayer shell. Microbubbles can be engineered through …

[HTML][HTML] The influence of inter-bubble spacing on the resonance response of ultrasound contrast agent microbubbles

H Yusefi, B Helfield - Ultrasonics Sonochemistry, 2022 - Elsevier
Ultrasound-driven microbubbles, typically between 1 and 8 µm in diameter, are resonant
scatterers that are employed as diagnostic contrast agents and emerging as potentiators of …

[HTML][HTML] Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles

AJ Sojahrood, H Haghi, R Karshafian… - Ultrasonics Sonochemistry, 2021 - Elsevier
In many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase
their stability. However, the complex behavior of the lipid coating including buckling and …

[HTML][HTML] Sonobactericide: an emerging treatment strategy for bacterial infections

KR Lattwein, H Shekhar, JJP Kouijzer… - Ultrasound in medicine …, 2020 - Elsevier
Ultrasound has been developed as both a diagnostic tool and a potent promoter of
beneficial bio-effects for the treatment of chronic bacterial infections. Bacterial infections …