Introduction: The neuropeptide calcitonin gene-related peptide (CGRP) is recognized as a
critical player in migraine pathophysiology. Excitement has grown regarding CGRP because …

Tactile and spontaneous pains are poorly managed symptoms of inflammatory and
neuropathic injury. Here, we found that transient receptor potential canonical 5 (TRPC5) is a …

Migraine is one of the most prevalent and disabling neurovascular disorders worldwide.
However, despite the increase in awareness and research, the understanding of migraine …

Background Despite high efficacy and tolerability, not all patients with chronic migraine
benefit from anti-CGRP monoclonal antibodies. We aimed to identify the clinical predictors of …

Abstract Calcitonin Gene-Related Peptide (CGRP) plays a pivotal role in migraine
pathophysiology. Two types of CGRP function-blocking modalities, monoclonal antibodies …

Background An increasing number of studies have suggested that the important role of
vasoactive peptides, such as pituitary adenylate cyclase-activating polypeptide-38 (PACAP …

Introduction Clinically, calcitonin gene-related peptide antagonising drugs are recognized
as effective in migraine treatment, but their site of action is debated. Only a small fraction of …

Objective To assess the real‐world efficacy, tolerability, and safety of ubrogepant in a tertiary
headache center. Background The efficacy and safety of ubrogepant for the acute treatment …

Objective The association between serum vitamin D and migraine is investigated in this
research. s Background Although the pathogenesis of migraine headache is not fully …

Background Non-invasive vagus nerve stimulation (nVNS) is a proven treatment for cluster
headache and migraine. Several possible mechanisms of action by which nVNS mitigates …