Aging is related to a variety of physiological organ changes, including central and peripheral
nervous systems. It has been reported that the orexin signaling has a potential analgesic …

Migraine is the seventh most disabling disorder globally, with prevalence of 11.7%
worldwide. One of the prevailing mechanisms is the activation of the trigeminovascular …

Background: The aim of this study was to evaluate the correlation between endothelial nitric
oxide synthase (eNOS) polymorphism (− 786T> C) and migraine susceptibility in a meta …

Although migraine is a common neurological condition, the pathomechanism is not yet fully
understood. Activation of the trigeminovascular system (TVS) has an important function in …

Objective: Phase II/III randomized clinical trials (RCTs) are vulnerable to many types of bias
beyond randomization. Insights into the reporting quality of RCTs involving migraine patients …

Gain-of-function mutations in the human CaV2. 1 gene CACNA1A cause familial hemiplegic
migraine type 1 (FHM1). To characterize cellular problems potentially triggered by CaV2. 1 …

Background: Functional gastrointestinal disorders (FGIDs) are chronic and recurrent
disorders, which affect up to 23% of children and adolescents and represent 50% of …

Purpose: Calcitonin gene-related peptide (CGRP) is an effector of acute migraine attack.
And the CGRP antagonisms have shown some early promise in the treatment of migraine …

Migraine and epilepsy are classified as chronic paroxysmal neurologic disorders sharing
many clinical features, as well as possible treatment options. This review highlights the …

Background. Migraine is a neurological disorder that results in disability accumulation, and
there are no blood‐based markers for indicating migraine susceptibility. Here, we aimed to …