The pathological assessment of surgical specimens during surgery can reduce the
incidence of positive resection margins, which otherwise can result in additional surgeries or …

Obtaining frozen sections of bone tissue for intraoperative examination is challenging. To
identify the bony edge of resection, orthopaedic oncologists therefore rely on pre-operative …

For the 1.7 million patients per year in the US who receive a new cancer diagnosis,
treatment decisions are largely based on histopathological specimen examinations …

Context.—The rapid evolution of optical imaging modalities in recent years has opened the
opportunity for ex vivo tissue imaging, which has significant implications for surgical …

Microscopic evaluation of resected tissue plays a central role in the surgical management of
cancer. Because optical microscopes have a limited depth-of-field (DOF), resected tissue is …

Histopathology relies upon the staining and sectioning of biological tissues, which can be
laborious and may cause artifacts and distort tissues. We develop label-free volumetric …

Objective To report the first application of ex vivo fluorescence confocal microscopy (FCM)‐a
novel optical technology that is capable of providing fast microscopic imaging of unfixed …

Rapid and high‐resolution histological imaging with minimal tissue preparation has long
been a challenging and yet captivating medical pursuit. Here, the authors propose a …

Real-time on-site histopathology review of biopsy tissues at the point-of-procedure has great
potential for significant clinical value and improved patient care. For instance, on-site review …

Histology involves the observation of structural features in tissues using a microscope. While
diffraction-limited optical microscopes are commonly used in histological investigations, their …