Multi-target drug discovery is one of the most followed approaches in the active central
nervous system (CNS) therapeutic area, especially in the search for new drugs against …

Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many
failures in living organism and ultimately in death. Organophosphorus compounds …

Abstract A number of N-(2-(1H-indol-3-yl) ethyl)-2-oxo-2H-chromene-3-carboxamides were
synthesized and tested against AChE and BuChE. The in vitro assessment of the …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …

In the nineties, numerous studies began to highlight the problem of the increasing number of
people with Alzheimer's disease in developed countries, especially in the context of …

Combining N-benzylpiperidine moiety of donepezil and coumarin into in a single molecule,
novel hybrids with ChE and MAO-B inhibitory activity were designed and synthesized. The …

Current possibilities of Alzheimer's disease (AD) treatment are very limited and are based on
administration of cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or N …

Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed
based on multi-target directed ligands (MTLDs) paradigm, synthesized and evaluated in …

A novel series of 7-methoxytacrine (7-MEOTA)–donepezil like compounds was synthesized
and tested for their ability to inhibit electric eel acetylcholinesterase (EeAChE), human …

Tacrine was withdrawn from clinical use as a drug against Alzheimer's disease in 2013,
mainly due to drug-induced liver injury. The culprit of tacrine-associated hepatotoxicity is …