Alzheimer's disease (AD) is a neurodegenerative disorder which is characterized by β-
amyloid (Aβ) aggregation, τ-hyperphosphorylation, and loss of cholinergic neurons. The …

Alzheimer's disease (AD) is a chronic neurodegenerative disease that 4 widespread in the
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …

Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are
useful agents as pesticides, but also represent a serious health hazard. Standard therapy …

The development of multitarget compounds against multifactorial diseases, such as
Alzheimer's disease, is an area of very intensive research, due to the expected superior …

Current options for Alzheimer's disease (AD) treatment are based on administration of
cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or memantine, acting …

The mechanism of tacrine as a precognitive drug has been considered to be complex and
not fully understood. It has been reported to involve a wide spectrum of targets involving …

A series of tacrine–benzothiazole hybrids incorporate inhibitors of acetylcholinesterase
(AChE), amyloid β (Aβ) aggregation and mitochondrial enzyme ABAD, whose interaction …

One undescribed indole alkaloid together with twenty-two known compounds have been
isolated from aerial parts of Vinca minor L.(Apocynaceae). The chemical structures of the …

Berberine, a naturally occurring compound, possesses an interesting multipotent
pharmacological profile potentially applicable for Alzheimer's disease (AD) treatment. In this …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss and deficits in cognitive domains. Low choline levels, oxidative stress, and …