A novel series of 6-chlorotacrine-scutellarin hybrids was designed, synthesized and the
biological activity as potential anti-Alzheimer's agents was assessed. Their inhibitory activity …

In search of potent acetyl cholinesterase inhibitors with low hepatotoxicity for the treatment of
Alzheimer's disease, introduction of a chloro substitution to tacrine and some of its analogs …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and currently there is
no efficient treatment. The classic drug-design strategy based on the “one-molecule-one …

Tianeptine was linked to various 9-aminoalkylamino-1, 2, 3, 4-tetrahydroacridines using
EDC· HCl/HOBt to afford a series of tacrine-tianeptine hybrids. The hybrids were tested for …

Since 2002, no clinical candidate against Alzheimer's disease has reached the market;
hence, an effective therapy is urgently needed. We followed the so-called “multitarget …

Tacrine was the first drug to be approved for Alzheimer's disease (AD) treatment, acting as a
cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile …

A series of OA-tacrine hybrids with the alkylamine linker was designed, synthesized, and
evaluated as effective cholinesterase inhibitors for the treatment of Alzheimer's disease …

Abstract New tetrahydro-1H-pyrazolo [3, 4-b] quinoline derivatives were designed,
synthesized and characterized as dual anticholinestrase and cyclooxygenase-2 inhibitors …

Background: 6-chlorotacrine is a cholinesterase inhibitor showing good inhibitory potential,
even better than parent compound tacrine, in vitro. Despite tacrine scaffold is broadly used …

Alzheimer's disease (AD) is a debilitating progressive neurodegenerative disorder that
ultimately leads to the patient's death. Despite the fact that novel pharmacological …