Alzheimer disease (AD) is characterized by a low level of acetylcholine, beta-amyloid (Aβ)
aggregation and oxidative stress. Donepezil is the core medicine used for the treatment of …

Tacrine was the first drug used in the therapy of Alzheimer's disease (AD) and is one of the
leading structures frequently pursued in the drug discovery of novel candidates for tackling …

ABSTRACT As the World Health Organization reports, mental illnesses have a serious
impact on more than 25% of all population people worldwide at some time during their lives …

Therapeutic options for Alzheimer's disease are limited. Dual compounds targeting two
pathways concurrently may enable enhanced effect. The study focuses on tacrine …

Herein we describe the synthesis and in vitro biological evaluation of thirteen new, racemic,
diversely functionalized imidazo pyranotacrines as non-hepatotoxic, multipotent tacrine …

Cholinesterase enzymes are important targets for the therapy of Alzheimer's disease.
Tacrine-based dual binding site cholinesterases inhibitors are potential disease-modifying …

Alzheimer's Disease (AD) is a multifactorial incurable neurodegenerative disorder. It is
characterized by a decline of cholinergic function in parallel with β-amyloid fibril deposition …

Impairment of mitochondrial metabolism, particularly the electron transport chain (ETC), as
well as increased oxidative stress might play a significant role in pathogenesis of …

Background: Due to the complex etiology of neurodegenerative diseases, there is growing
interest in multitarget drugs. In this study we synthesized and evaluated a new series of …

Chemical warfare agents constitute an increasing threat to both military and civilian
populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we …