Alzheimer's disease (AD) is a complex disease with an unknown etiology. Available
treatments, limited to cholinesterase inhibitors and N-methyl-d-aspartate receptor (NMDAR) …

Treatment of intoxications caused by nerve agents and organophosphorus pesticides
consists of different approaches. The first approach is called prophylaxis or pre-exposure …

Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have
been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti …

Insecticides represent the most crucial element in the integrated management approach to
malaria and other vector-borne diseases. The evolution of insect resistance to long-used …

Aim: Due to the complex nature of Alzheimer's disease, there is a renewed search for
multipotent, nonhepatotoxic tacrines. Results: This paper describes the synthesis and in vitro …

The search for novel and effective therapeutics for Alzheimer's disease (AD) is the main
quest that remains to be resolved. The goal is to find a disease-modifying agent able to …

Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder, and
represents the most common form of dementia. The number of people affected by AD is …

Inhibitors of cholinesterase are important drugs for therapy of Alzheimer's disease and the
search for new modifications is extensive, including dual inhibitors or multi-target hybrid …

Background: Alzheimer´ s disease (AD) is a serious and complex neurodegenerative
disease. Currently, there are about 44 million people suffering from AD all over the world …

The search for tacrine derivatives, as potential Alzheimer´ s disease treatment, is still being
at the forefront of scientific efforts. 7-MEOTA was found to be a potent, centrally active …