This review describes the synthesis of a wide range of novel tetrahydroacridine derivatives
(tiocyanates, selenocyanates, ureas, selenoureas, thioureas, isothioureas, disulfides …

Organophosphorus nerve agents inhibit acetylcholinesterase (AChE) which causes the
breakdown of the transmitter acetylcholine (ACh) in the synaptic cleft. Overstimulation of …

Organophosphates, useful agents as pesticides, also represent a serious danger due to
their high acute toxicity. There is indication that oximes, when administered before …

Alzheimer's disease (AD) is a complex disorder with unknown etiology. Currently, only
symptomatic therapy of AD is available, comprising cholinesterase inhibitors and N-methyl-d …

At present, demographic changes result in the growing number of older people. This trend
inevitably brings about serious social and economic issues, as well as occurrence of aging …

Alzheimer's disease (AD) is a multifactorial incurable neurodegenerative disorder. To date,
cholinesterase inhibitors (ChEI) are the mainstay line of treatment to ameliorate the …

The objective of this study was to elucidate the pharmacokinetics and metabolite formation
of newly developed non‐selective AC hE/BC hE 7‐MEOTA‐donepezil‐like inhibitors for …

Background: Owing to the complex nature of Alzheimer's disease, there is a renewed and
growing search for multitarget non-toxic tacrines as simple, easily available drugs in order to …

Aim: Due to the complex nature of Alzheimer's disease, there is a renewed search for
multitarget directed drugs. Results: This paper describes the synthesis and in vitro biological …

Background: Based on the prevalence studies, the number of people suffering from
dementia will almost double every 20 years, to 65.7 million in 2030 and 115.4 million in …