Alzheimerova nemoc (AD) je nejčastější příčinou demence, přesto jsou současné možnosti
léčby AD limitovány a jsou založeny na podávání inhibitorů cholinesteráz a/nebo …

The trends of novel AD therapeutics are focused on multitarget-directed ligands (MTDLs),
which combine cholinesterase inhibition with additional biological properties such as …

New tetrahydroquinoline derivatives were synthesized, characterized, and evaluated for
their in vitro and in vivo acetylcholinesterase inhibitory activity as well as hepatotoxicity …

Acetylcholinesterase inhibitors (AChEIs) are used in the treatment of myasthenia gravis
(MG). We investigated the effects of AChEIs on peripheral nicotinic receptors (nAChR) …

Background: Esterase is an enzyme that splits esters into an acid and alcohol. Varieties of
esterases are present in human body to control diverse set of cellular processes and …

A simple, rapid and sensitive method based on liquid chromatography–tandem mass
spectrometry (LC–MS/MS) has been developed and validated for the quantitative …

Novel types of symmetric bis‐7‐methoxytacrines connected by oligoethyleneoxy chains 3–5
and nonsymmetric monomeric 7‐methoxytacrines containing hydroxyl‐terminated …

Aim: Organophosphorus compounds are irreversible inhibitors of AChE. Without immediate
countermeasure, intoxication leads quickly to death. None of the clinically-used causal …

Background: Reversible acetylcholinesterase inhibitors are used in Alzheimer disease
therapy. However, tacrine and its derivatives have severe side effects. Derivatives of the …

Insects have a huge impact on quality of life around the world. They play roles in transmitting
diseases, crop-destruction, and as residential pests. Their increased resistance to the …