Výzkum nových léčiv u Alzheimerovy choroby
J Hroudová - Farmacie pro praxi, 2017 - solen.cz
Alzheimerova nemoc (AD) je nejčastější příčinou demence, přesto jsou současné možnosti
léčby AD limitovány a jsou založeny na podávání inhibitorů cholinesteráz a/nebo …
léčby AD limitovány a jsou založeny na podávání inhibitorů cholinesteráz a/nebo …
Effects of novel tacrine derivatives on mitochondrial energy metabolism and monoamine oxidase activity—in vitro study
J Hroudová, T Nováková, J Korábečný, D Maliňák… - Molecular …, 2021 - Springer
The trends of novel AD therapeutics are focused on multitarget-directed ligands (MTDLs),
which combine cholinesterase inhibition with additional biological properties such as …
which combine cholinesterase inhibition with additional biological properties such as …
Synthesis and biological evaluation of some tacrine analogs: study of the effect of the chloro substituent on the acetylcholinesterase inhibitory activity
New tetrahydroquinoline derivatives were synthesized, characterized, and evaluated for
their in vitro and in vivo acetylcholinesterase inhibitory activity as well as hepatotoxicity …
their in vitro and in vivo acetylcholinesterase inhibitory activity as well as hepatotoxicity …
[PDF][PDF] The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor
V Sepsova, J Krusek, J Zdarova Karasova, F Zemek… - Physiol Res, 2014 - researchgate.net
Acetylcholinesterase inhibitors (AChEIs) are used in the treatment of myasthenia gravis
(MG). We investigated the effects of AChEIs on peripheral nicotinic receptors (nAChR) …
(MG). We investigated the effects of AChEIs on peripheral nicotinic receptors (nAChR) …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for esterase inhibitors
Background: Esterase is an enzyme that splits esters into an acid and alcohol. Varieties of
esterases are present in human body to control diverse set of cellular processes and …
esterases are present in human body to control diverse set of cellular processes and …
An HPLC–MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a …
M Mzik, J Korabecny, E Nepovimova, V Voříšek… - … of Chromatography B, 2016 - Elsevier
A simple, rapid and sensitive method based on liquid chromatography–tandem mass
spectrometry (LC–MS/MS) has been developed and validated for the quantitative …
spectrometry (LC–MS/MS) has been developed and validated for the quantitative …
Preparation of 7‐Methoxy Tacrine Dimer Analogs and Their In vitro/In silico Evaluation as Potential Cholinesterase Inhibitors
SK Lee, MK Park, HE Jhang, J Yi… - Bulletin of the …, 2015 - Wiley Online Library
Novel types of symmetric bis‐7‐methoxytacrines connected by oligoethyleneoxy chains 3–5
and nonsymmetric monomeric 7‐methoxytacrines containing hydroxyl‐terminated …
and nonsymmetric monomeric 7‐methoxytacrines containing hydroxyl‐terminated …
Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase
L Gorecki, L Junova, T Kucera… - Future Medicinal …, 2019 - Taylor & Francis
Aim: Organophosphorus compounds are irreversible inhibitors of AChE. Without immediate
countermeasure, intoxication leads quickly to death. None of the clinically-used causal …
countermeasure, intoxication leads quickly to death. None of the clinically-used causal …
Inhibitors of acetylcholinesterase derived from 7-methoxytacrine and their effects on the choline transporter CHT1
Z Kristofikova, J Ricny, O Soukup… - Dementia and Geriatric …, 2017 - karger.com
Background: Reversible acetylcholinesterase inhibitors are used in Alzheimer disease
therapy. However, tacrine and its derivatives have severe side effects. Derivatives of the …
therapy. However, tacrine and its derivatives have severe side effects. Derivatives of the …
[HTML][HTML] Bis-isoquinolinium and bis-pyridinium acetylcholinesterase inhibitors: in vitro screening of probes for novel selective insecticides
V Hrabcova, J Korabecny, B Manyova, L Matouskova… - RSC …, 2017 - pubs.rsc.org
Insects have a huge impact on quality of life around the world. They play roles in transmitting
diseases, crop-destruction, and as residential pests. Their increased resistance to the …
diseases, crop-destruction, and as residential pests. Their increased resistance to the …