Deciphering cell–cell interactions and communication from gene expression

E Armingol, A Officer, O Harismendy… - Nature Reviews …, 2021 - nature.com
Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …

Origins of lifetime health around the time of conception: causes and consequences

TP Fleming, AJ Watkins, MA Velazquez, JC Mathers… - The Lancet, 2018 - thelancet.com
Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

Communication and quorum sensing in non-living mimics of eukaryotic cells

H Niederholtmeyer, C Chaggan, NK Devaraj - Nature communications, 2018 - nature.com
Cells in tissues or biofilms communicate with one another through chemical and mechanical
signals to coordinate collective behaviors. Non-living cell mimics provide simplified models …

lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

K Daneshvar, MB Ardehali, IA Klein, FK Hsieh… - Nature cell …, 2020 - nature.com
Cooperation between DNA, RNA and protein regulates gene expression and controls
differentiation through interactions that connect regions of nucleic acids and protein domains …

TCR signal strength and T cell development

NRJ Gascoigne, V Rybakin, O Acuto… - Annual review of cell …, 2016 - annualreviews.org
Thymocyte selection involves the positive and negative selection of the repertoire of T cell
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …

SERGIO: a single-cell expression simulator guided by gene regulatory networks

P Dibaeinia, S Sinha - Cell systems, 2020 - cell.com
A common approach to benchmarking of single-cell transcriptomics tools is to generate
synthetic datasets that statistically resemble experimental data. However, most existing …

[HTML][HTML] Electrical stimulation of titanium to promote stem cell orientation, elongation and osteogenesis

JS Khaw, R Xue, NJ Cassidy, SH Cartmell - Acta Biomaterialia, 2022 - Elsevier
Electrical stimulation of cells allows exogenous electric signals as stimuli to manipulate cell
growth, preferential orientation and bone remodelling. In this study, commercially pure …

Mitochondria lead the way: mitochondrial dynamics and function in cellular movements in development and disease

S Madan, B Uttekar, S Chowdhary… - Frontiers in Cell and …, 2022 - frontiersin.org
The dynamics, distribution and activity of subcellular organelles are integral to regulating
cell shape changes during various physiological processes such as epithelial cell formation …

Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models

K Reynolds, P Kumari… - Disease models & …, 2019 - journals.biologists.com
Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

Huntington disease as a neurodevelopmental disorder and early signs of the disease in stem cells

K Wiatr, WJ Szlachcic, M Trzeciak, M Figlerowicz… - Molecular …, 2018 - Springer
Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …