Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

R Wang - Physiological reviews, 2012 - journals.physiology.org
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

Hydrogen sulphide and its therapeutic potential

C Szabó - Nature reviews Drug discovery, 2007 - nature.com
Hydrogen sulphide (H2S) is increasingly being recognized as an important signalling
molecule in the cardiovascular and nervous systems. The production of H2S from l-cysteine …

[HTML][HTML] Sulfide catabolism ameliorates hypoxic brain injury

E Marutani, M Morita, S Hirai, S Kai… - Nature …, 2021 - nature.com
The mammalian brain is highly vulnerable to oxygen deprivation, yet the mechanism
underlying the brain's sensitivity to hypoxia is incompletely understood. Hypoxia induces …

Oxidant signals and oxidative stress

T Finkel - Current opinion in cell biology, 2003 - Elsevier
Although oxidants clearly possess the capacity to behave in a random and destructive
fashion, growing evidence suggests that in many instances the production of reactive …

Making and working with hydrogen sulfide: the chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: a review

MN Hughes, MN Centelles, KP Moore - Free Radical Biology and Medicine, 2009 - Elsevier
Hydrogen sulfide is rapidly emerging as an important vasoactive mediator formed in health
and disease. Its biological action is centered on its reactivity with heme-proteins and its …

Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells

LA Montoya, MD Pluth - Chemical communications, 2012 - pubs.rsc.org
Hydrogen sulfide (H2S) is an important biological messenger but few biologically-
compatible methods are available for its detection. Here we report two bright fluorescent …

Hydrogen sulfide: advances in understanding human toxicity

TL Guidotti - International journal of toxicology, 2010 - journals.sagepub.com
Hydrogen sulfide is a relatively common, frequently lethal, and unique occupational hazard
for which research since 1990 has uncovered many anomalies and subtleties and a …

[HTML][HTML] H2S biogenesis by human cystathionine γ-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of …

T Chiku, D Padovani, W Zhu, S Singh, V Vitvitsky… - Journal of Biological …, 2009 - ASBMB
Although there is a growing recognition of the significance of hydrogen sulfide (H 2 S) as a
biological signaling molecule involved in vascular and nervous system functions, its …

Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models

LF Hu, M Lu, CX Tiong, GS Dawe, G Hu, JS Bian - Aging cell, 2010 - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive
loss of dopaminergic neurons in the substantia nigra (SN). The present study was designed …

Antioxidant and cell‐signaling functions of hydrogen sulfide in the central nervous system

U Shefa, MS Kim, NY Jeong… - Oxidative medicine and …, 2018 - Wiley Online Library
Hydrogen sulfide (H2S), a toxic gaseous molecule, plays a physiological role in regulating
homeostasis and cell signaling. H2S is produced from cysteine by enzymes, such as …