Assessment of atrial fibrillation (AF)-associated stroke risk is at present mainly based on
clinical risk scores such as CHADS2 and CHA2DS2-VASc, although these scores provide …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Background—Delayed afterdepolarizations (DADs) carried by Na+-Ca2+-exchange current
(INCX) in response to sarcoplasmic reticulum (SR) Ca2+ leak can promote atrial fibrillation …

Rationale: Understanding atrial fibrillation (AF) requires integrated understanding of ionic
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …

Structural remodelling occurring before, due to the underlying heart disease, and during
atrial fibrillation (AF) sets the stage for permanent AF. Current therapy in AF aims to maintain …

Inadequacies in current therapies for atrial fibrillation have made new drug development
crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In …

Atrial fibrillation (AF) causes important mortality and morbidity on a population-level. So far,
we do not have the means to prevent AF or AF-related complications adequately. Therefore …

Objectives: The aim of this study was to evaluate the prognostic value of high-sensitivity
troponin T (hs-TnT) in addition to clinical risk factors and the CHA2DS2VASc (congestive …

Pre-existing Ca2+ handling abnormalities constitute the arrhythmogenic substrate in
patients developing postoperative atrial fibrillation (POAF), a common complication after …

Atrial fibrillation is the most common type of cardiac arrhythmia, and is responsible for
substantial morbidity and mortality in the general population. Current treatments have …