Background The roles of plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in
atherosclerotic diseases were intensively analyzed, but the results of these studies were …

Strokes within pediatric populations are considered to be the 10th leading cause of death in
the United States of America, with over half of such events occurring in children younger …

The plasminogen activator inhibitor-1 (PAI-1) is a candidate gene for stroke based on PAI-
1's crucial role in fibrinolytic system. However, association studies have yielded conflicting …

Background: the PAI-1 rs1799889 polymorphism has been reported to be associated with
susceptibility to ischemic stroke. However, the results of previous studies have been …

Mechanisms of ischemic stroke in young adults are poorly understood. The aim of the study
was to investigate and compare the frequency of common variations in prothrombotic genes …

The role of genetic risk factors for ischemic stroke seems to be in particular significance in
pediatric patients. Numerous polymorphic variants of genes encoding proteins, that is …

Genetic variants of plasminogen activator inhibitor type 1 (PAI-1) gene have been suggested
to influence the PAI-1 transcription activity and PAI-1 levels as well as might be involved in …

Background Prolonged euglobulin clot lysis time (ECLT) and increased level of
plasminogen activator inhibitor-1 (PAI-1) were reported to be risk factors of arterial ischemic …

Inherited thrombophilias are well-established predisposing factors for venous
thromboembolism, but their role in arterial ischemic stroke (AIS) in children, remains unclear …

The advent of the genomic era has provided novel insights into the genetic architecture of
common complex diseases, such as thrombophilia and stroke. Since 2006, a growing …