Reactive oxygen species (ROS) is considered a double-edged sword. The slightly elevated
level of ROS helps in wound healing by inhibiting microbial infection. In contrast, excessive …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

The upregulation of heme oxygenase-1 (HO-1) is one of the most important mechanisms of
cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal …

Understanding the processes governing the ability of the heart to repair and regenerate after
injury is crucial for developing translational medical solutions. New avenues of exploration …

Blood vessel formation is a fundamental process for the development of organism and tissue
regeneration. Of importance, angiogenesis occurring during postnatal development is …

Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H2S) together make up a
family of biologically active gases (the so-called 'gaseous triumvirate') with an increasingly …

Abstract Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme
degradation processes. Out of three by-products of HO-1 activity, biliverdin, iron ions and …

Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to biologically active products:
carbon monoxide (CO), biliverdin, and ferrous iron. It participates in maintaining cellular …

Type-2 diabetes prevalence is continuing to rise worldwide due to physical inactivity and
obesity epidemic. Diabetes and fluctuations of blood sugar are related to multiple micro-and …

Heme oxygenase-1 (HO-1) degrades heme to carbon monoxide (CO), biliverdin, and ferrous
iron. As HO-1 expression is highly increased by stressful conditions, the major role of the …