Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers globally with a
mortality rate exceeding 95% and very limited therapeutic options. A hallmark of PDAC is its …

We synthesized a mitochondria-targeted honokiol (Mito-HNK) that facilitates its
mitochondrial accumulation; this dramatically increases its potency and efficacy against …

Pancreatic cancer carries a poor prognosis as most patients present with advanced disease
and preferred chemotherapy regimens offer only modest effects on survival. Risk factors …

Cancer continues to be the leading cause of death worldwide. Plants have a long history of
use in the treatment of cancer. Honokiol (HNK) is an important bioactive compound found in …

Polycystic kidney disease (PKD) is a common hereditary kidney disease with abnormal
proliferation and apoptosis of kidney cystic epithelial cells, eventually leading to chronic …

Mitochondria play a central and multifunctional role in the progression of tumorigenesis.
Although many recent studies have demonstrated correlations between mitochondrial …

Metabolic heterogeneity within the tumor microenvironment promotes cancer cell growth
and immune suppression. We determined the impact of mitochondria-targeted complex I …

Targeting cancer cell metabolism is a promising strategy against cancer. Here, we confirmed
that the anti-cancer drug carboxyamidotriazole (CAI) inhibited mitochondrial respiration in …

Metformin has been used for nearly a century to treat type 2 diabetes mellitus. Epidemiologic
studies first identified the association between metformin and reduced risk of several …

Pancreatic cancer remains a lethal disease with limited treatment options. At the time of
diagnosis, approximately 80% of these patients present with unresectable tumors caused by …