Tetraspanins at a glance
S Charrin, S Jouannet, C Boucheix… - Journal of cell …, 2014 - journals.biologists.com
Tetraspanins are a family of proteins with four transmembrane domains that play a role in
many aspects of cell biology and physiology; they are also used by several pathogens for …
many aspects of cell biology and physiology; they are also used by several pathogens for …
Tetraspanins function as regulators of cellular signaling
CM Termini, JM Gillette - Frontiers in cell and developmental biology, 2017 - frontiersin.org
Tetraspanins are molecular scaffolds that distribute proteins into highly organized
microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have …
microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have …
Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature
Exosomes are 40–100-nm-diameter nanovesicles of endocytic origin that are released from
diverse cell types. To better understand the biological role of exosomes and to avoid …
diverse cell types. To better understand the biological role of exosomes and to avoid …
Tetraspanins: push and pull in suppressing and promoting metastasis
M Zöller - Nature Reviews Cancer, 2009 - nature.com
Tumours progress through a cascade of events that enable the formation of metastases.
Some of the components that are required for this fatal process are well established …
Some of the components that are required for this fatal process are well established …
Akt-ing up just about everywhere: compartment-specific Akt activation and function in receptor tyrosine kinase signaling
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
Prostate cancer sheds the αvβ3 integrin in vivo through exosomes
The αvβ3 integrin has been shown to promote aggressive phenotypes in many types of
cancers, including prostate cancer. We show that GFP-labeled αvβ3 derived from cancer …
cancers, including prostate cancer. We show that GFP-labeled αvβ3 derived from cancer …
Antibodies targeting cancer stem cells: a new paradigm in immunotherapy?
MP Deonarain, CA Kousparou, AA Epenetos - MAbs, 2009 - Taylor & Francis
Antibody targeting of cancer is showing clinical and commercial success after much intense
research and development over the last 30 years. They still have the potential to delivery …
research and development over the last 30 years. They still have the potential to delivery …
The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression
H Lazareth, C Henique, O Lenoir, VG Puelles… - Nature …, 2019 - nature.com
The mechanisms driving the development of extracapillary lesions in focal segmental
glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly …
glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly …
CD9, a tetraspanin target for cancer therapy?
A Lorico, M Lorico-Rappa… - Experimental …, 2021 - journals.sagepub.com
In the present minireview, we intend to provide a brief history of the field of CD9 involvement
in oncogenesis and in the metastatic process of cancer, considering its potential value as a …
in oncogenesis and in the metastatic process of cancer, considering its potential value as a …
Trop-2, Na+/K+ ATPase, CD9, PKCα, cofilin assemble a membrane signaling super-complex that drives colorectal cancer growth and invasion
E Guerra, V Relli, M Ceci, R Tripaldi, P Simeone… - Oncogene, 2022 - nature.com
Trop-2 is a transmembrane signal transducer that is overexpressed in most human cancers,
and drives malignant progression. To gain knowledge on the higher-order molecular …
and drives malignant progression. To gain knowledge on the higher-order molecular …