There has been steadily growing interest in the participation of metal ions (especially, zinc,
copper, and iron) in neurobiological processes, such as the regulation of synaptic …

As a disease-modifying approach for Alzheimer's disease (AD), clioquinol (CQ) targets β-
amyloid (Aß) reactions with synaptic Zn and Cu yet promotes metal uptake. Here we …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease. The brain
is particularly vulnerable to oxidative damage induced by unregulated redox-active metals …

Alzheimer's disease is the most common form of dementia in the elderly, and it is
characterized by elevated brain iron levels and accumulation of copper and zinc in cerebral …

There is a growing body of evidence to support a role for oxidative stress in Alzheimer's
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …

In this article, we first designed and synthesized curcumin-based near-infrared (NIR)
fluorescence imaging probes for detecting both soluble and insoluble amyloid beta (Aβ) …

The molecular bases underlying the pathogenesis of neurodegenerative diseases are
gradually being disclosed. One problem that investigators face is distinguishing primary from …

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …

BACKGROUND: Growing evidence suggests that oxidative damage caused by the β-
amyloid peptide in the pathogenesis of Alzheimer's disease may be hydrogen peroxide …

The chemistry of copper and iron plays a critical role in normal brain function. A variety of
enzymes and proteins containing positively charged Cu+, Cu2+, Fe2+, and Fe3+ control key …