Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22 …

Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a
daily cycle of feeding and fasting. In both animals and humans, TRF has pleiotropic health …

The circadian clock modulates human physiology. However, the organization of tissue-
specific gene expression rhythms and how these depend on age and sex is not defined in …

There is a growing interest in the role of timing of daily behaviors in improving health.
However, little is known about the optimal timing of physical activity to maximize health …

Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …

This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …