Increasing evidence indicates that the gut microbiome plays an important role in host aging
and sexual maturity. However, the gut microbial taxa associated with sexual maturity in …

Vascular aging is a potent driver of cardiovascular and cerebrovascular diseases. Vascular
aging features cellular and functional changes, while its molecular mechanisms and the cell …

Animal behavior emerges from integration of many processes with different spatial and
temporal scales. Dynamical behavioral patterns, including daily and ultradian rhythms and …

Biology of aging is an active and rapidly expanding area of biomedical research. Over the
years, focus of work in this field has been gradually shifting from studying the effects and …

Cellular circadian clocks, the molecular timers that coordinate physiology to the day/night
cycle across the domains of life, are widely regulated by disordereddisordered protein …

Nicotinamide adenine dinucleotide (NAD+) is a critical redox factor and coenzyme with
rhythmic availability, and reduced NAD+ levels are a common factor in many disease states …

Most organisms possess three biological oscillators, circadian clock, cell cycle, and redox
rhythm, which are autonomous but interact each other. However, whether their interactions …

The circadian clock is a fundamental biological mechanism that orchestrates essential
cellular and physiological processes to optimize fitness and health. The basic functional unit …

Aging has been proven to be one of the major causes of temporomandibular joint (TMJ)
disability and pain in older people. Peripheral circadian rhythms play a crucial role in …

Ageing is a universal decline of physiological functions accompanied by an increase in risks
of developing morbidity, diseases, and death. Calorie restriction (CR) without malnutrition …