Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
[HTML][HTML] Neonatal gut microbiome and immunity
KZ Sanidad, MY Zeng - Current opinion in microbiology, 2020 - Elsevier
Highlights•In utero microbial stimulation modulates both prenatal and postnatal immune cell
development.•Unique neonatal gut microenvironment allows for progressive colonization of …
development.•Unique neonatal gut microenvironment allows for progressive colonization of …
Gut microbiota resilience: definition, link to health and strategies for intervention
SK Dogra, J Doré, S Damak - Frontiers in microbiology, 2020 - frontiersin.org
The gut microbiota is a new frontier in health and disease. Not only many diseases are
associated with perturbed microbiota, but an increasing number of studies point to a cause …
associated with perturbed microbiota, but an increasing number of studies point to a cause …
Gut microbiota-induced changes in β-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder
S Leclercq, T Le Roy, S Furgiuele, V Coste, LB Bindels… - Cell Reports, 2020 - cell.com
Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and
social impairments. The gut microbiota has been recently shown to regulate brain functions …
social impairments. The gut microbiota has been recently shown to regulate brain functions …
Microbiota-brain interactions: Moving toward mechanisms in model organisms
Changes in the microbiota are associated with alterations in nervous system structure-
function and behavior and have been implicated in the etiology of neuropsychiatric and …
function and behavior and have been implicated in the etiology of neuropsychiatric and …
[HTML][HTML] Mining microbes for mental health: determining the role of microbial metabolic pathways in human brain health and disease
S Spichak, TFS Bastiaanssen, K Berding… - Neuroscience & …, 2021 - Elsevier
There is increasing knowledge regarding the role of the microbiome in modulating brain and
behaviour. Indeed, the actions of microbial metabolites are key for appropriate gut-brain …
behaviour. Indeed, the actions of microbial metabolites are key for appropriate gut-brain …
Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents
R Jabarin, S Netser, S Wagner - Molecular Autism, 2022 - Springer
Main In recent years, substantial advances in social neuroscience have been realized,
including the generation of numerous rodent models of autism spectrum disorder. Still, it can …
including the generation of numerous rodent models of autism spectrum disorder. Still, it can …
Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review
The emerging role of a microbiota‐gut‐brain axis in autism spectrum disorder (ASD)
suggests that modulating gut microbial composition may offer a tractable approach to …
suggests that modulating gut microbial composition may offer a tractable approach to …
The microbiota and the hypothalamus-pituitary-adrenocortical (HPA) axis, implications for anxiety and stress disorders
Highlights•Stressful events during the perinatal period are associated with dysbiosis in the
offspring.•Stress in early life can impact the development and functioning of the …
offspring.•Stress in early life can impact the development and functioning of the …