Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier

J Li, M Zheng, O Shimoni, WA Banks, AI Bush… - Advanced …, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

[HTML][HTML] Neonatal gut microbiome and immunity

KZ Sanidad, MY Zeng - Current opinion in microbiology, 2020 - Elsevier
Highlights•In utero microbial stimulation modulates both prenatal and postnatal immune cell
development.•Unique neonatal gut microenvironment allows for progressive colonization of …

Gut microbiota resilience: definition, link to health and strategies for intervention

SK Dogra, J Doré, S Damak - Frontiers in microbiology, 2020 - frontiersin.org
The gut microbiota is a new frontier in health and disease. Not only many diseases are
associated with perturbed microbiota, but an increasing number of studies point to a cause …

Gut microbiota-induced changes in β-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder

S Leclercq, T Le Roy, S Furgiuele, V Coste, LB Bindels… - Cell Reports, 2020 - cell.com
Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and
social impairments. The gut microbiota has been recently shown to regulate brain functions …

Microbiota-brain interactions: Moving toward mechanisms in model organisms

J Nagpal, JF Cryan - Neuron, 2021 - cell.com
Changes in the microbiota are associated with alterations in nervous system structure-
function and behavior and have been implicated in the etiology of neuropsychiatric and …

[HTML][HTML] Mining microbes for mental health: determining the role of microbial metabolic pathways in human brain health and disease

S Spichak, TFS Bastiaanssen, K Berding… - Neuroscience & …, 2021 - Elsevier
There is increasing knowledge regarding the role of the microbiome in modulating brain and
behaviour. Indeed, the actions of microbial metabolites are key for appropriate gut-brain …

Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents

R Jabarin, S Netser, S Wagner - Molecular Autism, 2022 - Springer
Main In recent years, substantial advances in social neuroscience have been realized,
including the generation of numerous rodent models of autism spectrum disorder. Still, it can …

Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review

Q Tan, CE Orsso, EC Deehan, JY Kung… - Autism …, 2021 - Wiley Online Library
The emerging role of a microbiota‐gut‐brain axis in autism spectrum disorder (ASD)
suggests that modulating gut microbial composition may offer a tractable approach to …

The microbiota and the hypothalamus-pituitary-adrenocortical (HPA) axis, implications for anxiety and stress disorders

LM Frankiensztajn, E Elliott, O Koren - Current opinion in neurobiology, 2020 - Elsevier
Highlights•Stressful events during the perinatal period are associated with dysbiosis in the
offspring.•Stress in early life can impact the development and functioning of the …