Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …
Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …
AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …
Transarterial chemoembolization with PD-(L) 1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)
HD Zhu, HL Li, MS Huang, WZ Yang, GW Yin… - Signal transduction and …, 2023 - nature.com
There is considerable potential for integrating transarterial chemoembolization (TACE),
programmed death-(ligand) 1 (PD-[L] 1) inhibitors, and molecular targeted treatments (MTT) …
programmed death-(ligand) 1 (PD-[L] 1) inhibitors, and molecular targeted treatments (MTT) …
Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis
Z Xun, X Ding, Y Zhang, B Zhang, S Lai, D Zou… - Nature …, 2023 - nature.com
Although advances in spatial transcriptomics (ST) enlarge to unveil spatial landscape of
tissues, it remains challenging to delineate pathology-relevant and cellular localizations …
tissues, it remains challenging to delineate pathology-relevant and cellular localizations …
Critical appraisal of guideline recommendations on systemic therapies for advanced hepatocellular carcinoma: a review
S Cappuyns, V Corbett, M Yarchoan, RS Finn… - JAMA …, 2023 - jamanetwork.com
Importance The combination of immune checkpoint inhibitors with antiangiogenic agents
has revolutionized the treatment landscape of advanced hepatocellular carcinoma (HCC) …
has revolutionized the treatment landscape of advanced hepatocellular carcinoma (HCC) …
Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
Comprehensive molecular analyses of metastatic hepatocellular carcinoma (HCC) are
lacking. Here, we generate multi-omic profiling of 257 primary and 176 metastatic regions …
lacking. Here, we generate multi-omic profiling of 257 primary and 176 metastatic regions …
Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma
Liver cancer, specifically hepatocellular carcinoma (HCC), is the sixth most common cancer
and the third leading cause of cancer mortality worldwide. The development of effective …
and the third leading cause of cancer mortality worldwide. The development of effective …
Aberrant LYZ expression in tumor cells serves as the potential biomarker and target for HCC and promotes tumor progression via csGRP78
Z Gu, L Wang, Q Dong, K Xu, J Ye… - Proceedings of the …, 2023 - National Acad Sciences
Hepatocellular carcinoma (HCC) takes the predominant malignancy of hepatocytes with
bleak outcomes owing to high heterogeneity among patients. Personalized treatments …
bleak outcomes owing to high heterogeneity among patients. Personalized treatments …
[HTML][HTML] Sequential therapies after atezolizumab plus bevacizumab or lenvatinib first-line treatments in hepatocellular carcinoma patients
M Persano, M Rimini, T Tada, G Suda… - European Journal of …, 2023 - Elsevier
Introduction The aim of this retrospective proof-of-concept study was to compare different
second-line treatments for patients with hepatocellular carcinoma and progressive disease …
second-line treatments for patients with hepatocellular carcinoma and progressive disease …