Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment

JM Llovet, CE Willoughby, AG Singal… - Nature reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

AG Singal, JM Llovet, M Yarchoan, N Mehta… - Hepatology, 2023 - journals.lww.com
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …

Transarterial chemoembolization with PD-(L) 1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

HD Zhu, HL Li, MS Huang, WZ Yang, GW Yin… - Signal transduction and …, 2023 - nature.com
There is considerable potential for integrating transarterial chemoembolization (TACE),
programmed death-(ligand) 1 (PD-[L] 1) inhibitors, and molecular targeted treatments (MTT) …

Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis

Z Xun, X Ding, Y Zhang, B Zhang, S Lai, D Zou… - Nature …, 2023 - nature.com
Although advances in spatial transcriptomics (ST) enlarge to unveil spatial landscape of
tissues, it remains challenging to delineate pathology-relevant and cellular localizations …

Critical appraisal of guideline recommendations on systemic therapies for advanced hepatocellular carcinoma: a review

S Cappuyns, V Corbett, M Yarchoan, RS Finn… - JAMA …, 2023 - jamanetwork.com
Importance The combination of immune checkpoint inhibitors with antiangiogenic agents
has revolutionized the treatment landscape of advanced hepatocellular carcinoma (HCC) …

Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma

Y Sun, P Wu, Z Zhang, Z Wang, K Zhou, M Song, Y Ji… - Cancer Cell, 2024 - cell.com
Comprehensive molecular analyses of metastatic hepatocellular carcinoma (HCC) are
lacking. Here, we generate multi-omic profiling of 257 primary and 176 metastatic regions …

Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma

JM Llovet, R Pinyol, M Yarchoan, AG Singal… - Nature Reviews …, 2024 - nature.com
Liver cancer, specifically hepatocellular carcinoma (HCC), is the sixth most common cancer
and the third leading cause of cancer mortality worldwide. The development of effective …

Aberrant LYZ expression in tumor cells serves as the potential biomarker and target for HCC and promotes tumor progression via csGRP78

Z Gu, L Wang, Q Dong, K Xu, J Ye… - Proceedings of the …, 2023 - National Acad Sciences
Hepatocellular carcinoma (HCC) takes the predominant malignancy of hepatocytes with
bleak outcomes owing to high heterogeneity among patients. Personalized treatments …

[HTML][HTML] Sequential therapies after atezolizumab plus bevacizumab or lenvatinib first-line treatments in hepatocellular carcinoma patients

M Persano, M Rimini, T Tada, G Suda… - European Journal of …, 2023 - Elsevier
Introduction The aim of this retrospective proof-of-concept study was to compare different
second-line treatments for patients with hepatocellular carcinoma and progressive disease …