Phosphatidylethanolamine homeostasis under conditions of impaired CDP-ethanolamine pathway or phosphatidylserine decarboxylation

M St Germain, R Iraji, M Bakovic - Frontiers in Nutrition, 2023 - frontiersin.org
Phosphatidylethanolamine is the major inner-membrane lipid in the plasma and
mitochondrial membranes. It is synthesized in the endoplasmic reticulum from ethanolamine …

Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activity

K Rahman, SAK Datta, AH Beaven, AA Jolley… - Journal of Molecular …, 2022 - Elsevier
The interferon-induced transmembrane (IFITM) proteins broadly inhibit the entry of diverse
pathogenic viruses, including Influenza A virus (IAV), Zika virus, HIV-1, and SARS …

Kinetic relaxation of giant vesicles validates diffusional softening in a binary lipid mixture

K Sapp, M Aleksanyan, K Kerr, R Dimova, A Sodt - Physical Review E, 2023 - APS
The stiffness of biological membranes determines the work required by cellular machinery to
form and dismantle vesicles and other lipidic shapes. Model membrane stiffness can be …

Simulated dynamic cholesterol redistribution favors membrane fusion pore constriction

AH Beaven, K Sapp, AJ Sodt - Biophysical Journal, 2023 - cell.com
Endo-and exocytosis proceed through a highly strained membrane fusion pore topology
regardless of the aiding protein machinery. The membrane's lipid components bias fusion …

Softening in two-component lipid mixtures by spontaneous curvature variance

A Hossein, AH Beaven, K Sapp… - The Journal of Physical …, 2023 - ACS Publications
The bending modulus of a lipid bilayer quantifies its mechanical resistance to curvature. It is
typically understood in terms of thickness; eg, thicker bilayers are usually stiffer. Here, we …

The full model of micropipette aspiration of cells: A mesoscopic simulation

Y Du, S Zhang, D Cheng, Y Liu, M Sun, Q Zhao, M Cui… - Acta Biomaterialia, 2023 - Elsevier
Studies on the interaction between cells and micromanipulation tools are necessary to
optimize the procedures and improve the developmental potential of cells. The molecular …

The Role of Lipid Intrinsic Curvature in the Droplet Interface Bilayer

J Gudyka, J Ceja-Vega, M Krmic, R Porteus, S Lee - Langmuir, 2024 - ACS Publications
Model bilayers are constructed from lipids having different intrinsic curvatures using the
droplet interface bilayer (DIB) method, and their static physicochemical properties are …

[PDF][PDF] MembraneAnalysis. jl: A Julia package for analyzing molecular dynamics simulations of lipid membranes

A Hossein, AJ Sodt - Journal of Open Source Software, 2023 - joss.theoj.org
Biological membranes separate living cells from their surroundings, and, in case of
eukaryotes, partition the cell into its constituent organelles. These bilayer structures, which …

Curvature-induced lipid sorting beyond the critical packing parameter

M Konig, R de Vries, F Grunewald, SJ Marrink… - bioRxiv, 2023 - biorxiv.org
Over the last few decades, the spatial organization of biomembranes has received a lot of
attention. With the fluid mosaic model, Singer and Nicolson proposed that biomembranes …

LEGO-lipophosphonoxins: length of hydrophobic module affects permeabilizing activity in target membranes of different phospholipid composition

M Dugić, H Brzobohatá, V Mojr, T Dolejšová… - RSC …, 2024 - pubs.rsc.org
In the past few decades, society has faced rapid development and spreading of
antimicrobial resistance due to antibiotic misuse and overuse and the immense adaptability …