[HTML][HTML] Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: a narrative review.

KA Alam, P Svalastoga, A Martinez, JC Glennon… - Neuroscience & …, 2023 - Elsevier
Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

[HTML][HTML] The link between cognition and somatic conditions related to insulin resistance in the UK Biobank study cohort: a systematic review

G Fanelli, NR Mota, J Salas-Salvado, M Bullo… - Neuroscience & …, 2022 - Elsevier
Clinical and genomic studies have shown an overlap between neuropsychiatric disorders
and insulin resistance (IR)-related somatic conditions, including obesity, type 2 diabetes …

Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

G Fanelli, B Franke, W De Witte, IH Ruisch… - Translational …, 2022 - nature.com
The prevalence of somatic insulinopathies, like metabolic syndrome (MetS), obesity, and
type 2 diabetes mellitus (T2DM), is higher in Alzheimer's disease (AD), autism spectrum …

Temporally ordered associations between type 2 diabetes and brain disorders–a Danish register-based cohort study

T Wimberley, HT Horsdal, I Brikell, TM Laursen… - BMC psychiatry, 2022 - Springer
Background Type 2 diabetes mellitus (T2DM) is linked with several neurodegenerative and
psychiatric disorders, either as a comorbid condition or as a risk factor. We aimed to expand …

A dimensional perspective on the genetics of obsessive-compulsive disorder

NI Strom, T Soda, CA Mathews, LK Davis - Translational Psychiatry, 2021 - nature.com
This review covers recent findings in the genomics of obsessive-compulsive disorder (OCD),
obsessive-compulsive symptoms, and related traits from a dimensional perspective. We …

[HTML][HTML] A systematic review of preclinical studies exploring the role of insulin signalling in executive function and memory

AM Ottomana, M Presta, A O'Leary, M Sullivan… - … & biobehavioral reviews, 2023 - Elsevier
Beside its involvement in somatic dysfunctions, altered insulin signalling constitutes a risk
factor for the development of mental disorders like Alzheimer's disease and obsessive …

Obsessive compulsive disorder and response inhibition: Meta-analysis of the stop-signal task.

K Mar, P Townes, P Pechlivanoglou… - … and clinical science, 2022 - psycnet.apa.org
This systematic review and meta-analysis updates evidence pertaining to response
inhibition in obsessive–compulsive disorder (OCD) as measured by the stop-signal task …

[HTML][HTML] Systematic review: molecular studies of common genetic variation in child and adolescent psychiatric disorders

WA Akingbuwa, AR Hammerschlag, M Bartels… - Journal of the American …, 2022 - Elsevier
Objective We conducted a systematic review of studies using molecular genetics and
statistical approaches to investigate the role of common genetic variation in the …

[HTML][HTML] Insulin and disorders of behavioural flexibility

M Sullivan, F Fernandez-Aranda… - … & biobehavioral reviews, 2023 - Elsevier
Behavioural inflexibility is a symptom of neuropsychiatric and neurodegenerative disorders
such as Obsessive-Compulsive Disorder, Autism Spectrum Disorder and Alzheimer's …

Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns

V Oliva, G Fanelli, S Kasper, J Zohar, D Souery… - Journal of Affective …, 2023 - Elsevier
Background Major depressive disorder (MDD) is a highly prevalent psychiatric condition
characterised by a heterogeneous clinical presentation and an estimated twin-based …