Healthy aging and human longevity are intricate phenotypes affected by environmental
factors such as physical exercise, diet, health habits, and psychosocial situations as well as …

This review offers a systematic understanding about how polyphenols target multiple
inflammatory components and lead to anti-inflammatory mechanisms. It provides a clear …

Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

Depression is one of the most debilitating psychiatric disorders affecting people of all ages
worldwide. Despite significant heterogeneity between studies, increased inflammation and …

The transcription factor nuclear factor-κB (NF-κB) modulates gene expression in diverse
cellular processes such as innate immune response, embryogenesis and organ …

Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the
spine. A series of factors, such as inflammation, oxidative stress and mechanical stress …

A large body of literature supports the idea that nuclear factor kappa B (NF-κB) signaling
contributes to not only immunity, but also inflammation, cancer, and nervous system function …

In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

Zinc is a nutritionally fundamental trace element, essential to the structure and function of
numerous macromolecules, including enzymes regulating cellular processes and cellular …