E3 ubiquitin ligases: styles, structures and functions
Q Yang, J Zhao, D Chen, Y Wang - Molecular biomedicine, 2021 - Springer
E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …
All about the RNA: interferon-stimulated genes that interfere with viral RNA processes
E Yang, MMH Li - Frontiers in immunology, 2020 - frontiersin.org
Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …
Structural principles of tumor necrosis factor superfamily signaling
ÉS Vanamee, DL Faustman - Science signaling, 2018 - science.org
The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …
BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma
JT Li, M Yin, D Wang, J Wang, MZ Lei, Y Zhang… - Nature cell …, 2020 - nature.com
Branched-chain amino acid (BCAA) metabolism is potentially linked with development of
pancreatic ductal adenocarcinoma (PDAC),,-. BCAA transaminase 2 (BCAT2) was essential …
pancreatic ductal adenocarcinoma (PDAC),,-. BCAA transaminase 2 (BCAT2) was essential …
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules
C Yang, Z Wang, Y Kang, Q Yi, T Wang, Y Bai, Y Liu - Autophagy, 2023 - Taylor & Francis
Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …
TRIM21/Ro52-roles in innate immunity and autoimmune disease
TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …
TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses
Autophagy, a main intracellular catabolic process, is induced in response to a variety of
cellular stresses to promptly degrade harmful agents and to coordinate the activity of …
cellular stresses to promptly degrade harmful agents and to coordinate the activity of …
MuRF1/TRIM63, master regulator of muscle mass
D Peris-Moreno, D Taillandier, C Polge - International journal of …, 2020 - mdpi.com
The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play
important roles during skeletal muscle atrophy. Since then, numerous studies have been …
important roles during skeletal muscle atrophy. Since then, numerous studies have been …
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53
P Jiang, L Ren, L Zhi, Z Yu, F Lv, F Xu, W Peng, X Bai… - Molecular cell, 2021 - cell.com
As a master regulator of metabolism, AMP-activated protein kinase (AMPK) is activated upon
energy and glucose shortage but suppressed upon overnutrition. Exaggerated negative …
energy and glucose shortage but suppressed upon overnutrition. Exaggerated negative …
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition
MG Koliopoulos, M Lethier, AG van der Veen… - Nature …, 2018 - nature.com
RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response
to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin …
to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin …