Oxidative stress in alzheimer's disease: A review on emergent natural polyphenolic therapeutics

L Cassidy, F Fernandez, JB Johnson, M Naiker… - … therapies in medicine, 2020 - Elsevier
Objectives The aim of this research was to review the literature on Alzheimer's disease (AD)
with a focus on polyphenolics as antioxidant therapeutics. Design This review included a …

Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress

Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

H Zhang, Y Wang, Y Wang, X Li, S Wang… - European Journal of …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease

N Kumar, V Kumar, P Anand, V Kumar… - Bioorganic & Medicinal …, 2022 - Elsevier
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology

C Albertini, A Salerno… - Medicinal Research …, 2021 - Wiley Online Library
The continued drug discovery failures in complex neurodegenerative diseases, including
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …

Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism

S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice

C Wang, X Cai, R Wang, S Zhai, Y Zhang, W Hu… - Journal of …, 2020 - Springer
Background Endoplasmic reticulum (ER) stress is involved in the progression of Alzheimer's
disease (AD). Verbascoside (VB), an active phenylethanoid glycoside that was first isolated …

Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregation

E Plazas, S Hagenow, MA Murillo, H Stark… - Bioorganic Chemistry, 2020 - Elsevier
Multifactorial neurodegenerative disorders such as Alzheimer's disease (AD) are considered
a growing public health problem due the rising incidence and low effectiveness of current …

Rational drug design strategies for the development of promising multi-target directed indole hybrids as Anti-Alzheimer agents

N George, MJ Akhtar, KA Al Balushi, SA Khan - Bioorganic Chemistry, 2022 - Elsevier
Alzheimer's disease (AD) is a neurological disorder that leads to dementia ie, progressive
memory loss accompanied with worsening of thinking ability of an individual. The cause of …

Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease

P Sharma, A Tripathi, PN Tripathi… - ACS chemical …, 2019 - ACS Publications
Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1, 3, 4-oxadiazoles
were designed, synthesized, and evaluated against Alzheimer's disease (AD). Tested …