The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor
that has multiple accessory functions during viral infection. In recent years, the major role …

Influenza virus infection of humans results in a respiratory disease that ranges in severity
from sub-clinical infection to primary viral pneumonia that can result in death. The clinical …

The mechanisms responsible for the virulence of the highly pathogenic avian influenza
(HPAI) and of the 1918 pandemic influenza virus in humans remain poorly understood. To …

Interferons (IFNs), which were discovered a half century ago, are a group of secreted
proteins that play key roles in innate immunity against viral infection. The major signaling …

Influenza viruses cause annual seasonal epidemics and occasional pandemics of human
respiratory disease. Influenza virus infections represent a serious public health and …

Influenza viruses are globally important human respiratory pathogens. These viruses cause
seasonal epidemics and occasional worldwide pandemics, both of which can vary …

The cellular immune response to primary influenza virus infection is complex, involving
multiple cell types and anatomical compartments, and is difficult to measure directly. Here …

Influenza viral infection represents a serious public health problem that causes contagious
respiratory disease, which is most effectively prevented through vaccination to reduce …

The interferon (IFN) induced anti-viral response is amongst the earliest and most potent of
the innate responses to fight viral infection. The induction of the Janus kinase/signal …

Influenza A viruses (IAV) can infect a broad range of animal hosts, including humans. In
humans, IAV causes seasonal annual epidemics and occasional pandemics, representing a …