Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy
PG Coulie, BJ Van den Eynde… - Nature Reviews …, 2014 - nature.com
In this Timeline, we describe the characteristics of tumour antigens that are recognized by
spontaneous T cell responses in cancer patients and the paths that led to their identification …
spontaneous T cell responses in cancer patients and the paths that led to their identification …
Cancer and the immune system: basic concepts and targets for intervention
D Pardoll - Seminars in oncology, 2015 - Elsevier
A number of consensuses regarding cancer immunology have recently emerged from both
preclinical immunotherapy models and analysis of cancer patients. First and foremost, the …
preclinical immunotherapy models and analysis of cancer patients. First and foremost, the …
Immune parameters affecting the efficacy of chemotherapeutic regimens
The outcome of chemotherapy can be influenced by the host immune system at multiple
levels. Chemotherapy can kill cancer cells by causing them to elicit an immune response or …
levels. Chemotherapy can kill cancer cells by causing them to elicit an immune response or …
The Tübingen approach: identification, selection, and validation of tumor-associated HLA peptides for cancer therapy
H Singh-Jasuja, NPN Emmerich… - Cancer Immunology …, 2004 - Springer
There is substantial need for molecularly defined tumor antigens to prime cytotoxic T cells in
vivo for cancer immunotherapy, especially in the case of tumor entities for which only a few …
vivo for cancer immunotherapy, especially in the case of tumor entities for which only a few …
[HTML][HTML] IL-10 elicits IFNγ-dependent tumor immune surveillance
JB Mumm, J Emmerich, X Zhang, I Chan, L Wu… - Cancer cell, 2011 - cell.com
Tumor immune surveillance and cancer immunotherapies are thought to depend on the
intratumoral infiltration of activated CD8+ T cells. Intratumoral CD8+ T cells are rare and lack …
intratumoral infiltration of activated CD8+ T cells. Intratumoral CD8+ T cells are rare and lack …
DNA vaccine for cancer immunotherapy
DNA vaccination has emerged as an attractive immunotherapeutic approach against cancer
due to its simplicity, stability, and safety. Results from numerous clinical trials have …
due to its simplicity, stability, and safety. Results from numerous clinical trials have …
[HTML][HTML] The biology of cancer testis antigens: putative function, regulation and therapeutic potential
E Fratta, S Coral, A Covre, G Parisi, F Colizzi… - Molecular …, 2011 - Elsevier
Cancer testis antigens (CTA) are a large family of tumor-associated antigens expressed in
human tumors of different histological origin, but not in normal tissues except for testis and …
human tumors of different histological origin, but not in normal tissues except for testis and …
From genes to drugs: targeted strategies for melanoma
KT Flaherty, FS Hodi, DE Fisher - Nature Reviews Cancer, 2012 - nature.com
The past decade has revealed that melanoma is comprised of multiple subclasses that can
be categorized on the basis of key features, including the clinical stage of disease, the …
be categorized on the basis of key features, including the clinical stage of disease, the …
Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes
A Van Tongelen, A Loriot, C De Smet - Cancer letters, 2017 - Elsevier
Global loss of DNA methylation is frequently observed in the genome of human tumors.
Although this epigenetic alteration is clearly associated with cancer progression, the way it …
Although this epigenetic alteration is clearly associated with cancer progression, the way it …
[HTML][HTML] Cancer vaccines: between the idea and the reality
OJ Finn - Nature Reviews Immunology, 2003 - nature.com
Whether vaccines are designed to prepare the immune system for the encounter with a
pathogen or with cancer, certain common challenges need to be faced, such as what …
pathogen or with cancer, certain common challenges need to be faced, such as what …