The bacterial infection of chorion and amnion is a common finding in premature delivery and
is referred to as chorioamnionitis. As the mother rarely shows symptoms of a systemic …

(PVL) in the premature newborn. Three meta-analyses have linked chorioamnionitis to cystic
PVL and cerebral palsy. Yet, the relationship between chorioamnionitis and brain injury was …

Background Increased systemic and tissue levels of interleukin (IL)-1β are associated with
greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis …

Objective: Preterm infants exhibit chronic deficits in white matter (WM) and cortical
maturation. Although fetal infection/inflammation may contribute to WM pathology, the factors …

Background Increased circulating levels of tumor necrosis factor (TNF) are associated with
greater risk of impaired neurodevelopment after preterm birth. In this study, we tested the …

Background Preterm newborns commonly experience apnoeas after birth and require
respiratory stimulants and support. Antenatal inflammation is a common antecedent of …

The K ennard principle suggests that the immature brain should be more able to recover
from injury than the more developed brain. Curiously, preterm infants continue to have a …

Progressive fetal infection/inflammation is strongly associated with neural injury after
preterm birth. We aimed to test the hypotheses that progressively developing fetal …

One of the central, unanswered questions in perinatology is why preterm infants continue to
have such poor long-term neurodevelopmental, cognitive and learning outcomes, even …

The impact of endotoxemia on cerebral endothelium and cerebral blood flow (CBF)
regulation was studied in conscious newborn lambs. Bacterial endotoxin [LPS, 2 μg/kg iv] …