[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Multiple neuroinvasive pathways in COVID-19

D Bougakov, K Podell, E Goldberg - Molecular neurobiology, 2021 - Springer
COVID-19 is a highly infectious viral disease caused by the novel coronavirus SARS-CoV-2.
While it was initially regarded as a strictly respiratory illness, the impact of COVID-19 on …

[HTML][HTML] Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial …

C Cui, P Xu, G Li, Y Qiao, W Han, C Geng, D Liao… - Redox biology, 2019 - Elsevier
Hypertension is one of the major predisposing factors for neurodegenerative disease
characterized with activated renin-angiotensin system (RAS) in both periphery and brain …

ACE2 in brain physiology and pathophysiology: evidence from transgenic animal models

N Alenina, M Bader - Neurochemical research, 2019 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2) is a protein consisting of two domains,
the N-terminus is a carboxypeptidase homologous to ACE and the C-terminus is …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the neuroendocrine stress axis

C Steenblock, V Todorov, W Kanczkowski… - Molecular …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in
December 2019, causes coronavirus disease 2019 (COVID-19). It is reasonable to presume …

ACE2 and ADAM17 interaction regulates the activity of presympathetic neurons

S Mukerjee, H Gao, J Xu, R Sato, A Zsombok… - …, 2019 - Am Heart Assoc
Brain renin angiotensin system within the paraventricular nucleus plays a critical role in
balancing excitatory and inhibitory inputs to modulate sympathetic output and blood …

ACE2 (Angiotensin-Converting Enzyme 2) in cardiopulmonary diseases: ramifications for the control of SARS-CoV-2

RK Sharma, BR Stevens, AG Obukhov, MB Grant… - …, 2020 - Am Heart Assoc
Discovery of ACE2 (angiotensin-converting enzyme 2) revealed that the renin-angiotensin
system has 2 counterbalancing arms. ACE2 is a major player in the protective arm, highly …

The renin–angiotensin system: a possible new target for depression

J Vian, C Pereira, V Chavarria, C Köhler, B Stubbs… - BMC medicine, 2017 - Springer
Depression remains a debilitating condition with an uncertain aetiology. Recently, attention
has been given to the renin–angiotensin system. In the central nervous system, angiotensin …

ACE2 mouse models: a toolbox for cardiovascular and pulmonary research

H Jia, X Yue, E Lazartigues - Nature communications, 2020 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry
receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible …

Impaired autonomic nervous system-microbiome circuit in hypertension: a premise for hypertension therapy

J Zubcevic, EM Richards, T Yang, S Kim… - Circulation …, 2019 - Am Heart Assoc
Hypertension affects an estimated 103 million Americans, yet gaps in knowledge continue to
limit its successful management. Rapidly emerging evidence is linking gut dysbiosis to many …