Plant protease inhibitors in therapeutics-focus on cancer therapy

S Srikanth, Z Chen - Frontiers in pharmacology, 2016 - frontiersin.org
Plants are known to have many secondary metabolites and phytochemical compounds
which are highly explored at biochemical and molecular genetics level and exploited …

Protease inhibitors from plants as therapeutic agents-a review

MS Cid-Gallegos, LJ Corzo-Ríos… - Plant Foods for Human …, 2022 - Springer
Plant-based diets are a great source of protease inhibitors (PIs). Two of the most well-known
families of PIs are Bowman-Birk inhibitors (BBI) and Kunitz-type inhibitors (KTI). The first …

The bHLH Transcription Factors TSAR1 and TSAR2 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula

J Mertens, J Pollier, R Vanden Bossche… - Plant …, 2016 - academic.oup.com
Plants respond to stresses by producing a broad spectrum of bioactive specialized
metabolites. Hormonal elicitors, such as jasmonates, trigger a complex signaling circuit …

Intestinal exposure to food-derived protease inhibitors: digestion physiology-and gut health-related effects

A Kårlund, I Paukkonen, C Gómez-Gallego… - Healthcare, 2021 - mdpi.com
Plant-derived protease inhibitors (PI), such as Bowman-Birk inhibitors and Kunitz-type
inhibitors, have been suggested to negatively affect dietary protein digestion by blocking the …

Plant kunitz inhibitors and their interaction with proteases: Current and potential pharmacological targets

CR Bonturi, AB Silva Teixeira, VM Rocha… - International Journal of …, 2022 - mdpi.com
The action of proteases can be controlled by several mechanisms, including regulation
through gene expression; post-translational modifications, such as glycosylation; zymogen …

Analysis of Kunitz inhibitors from plants for comprehensive structural and functional insights

AD Bendre, S Ramasamy, CG Suresh - International journal of biological …, 2018 - Elsevier
Legume Kunitz type trypsin inhibitor (KTI) family is one of the most versatile families of
proteins. A typical KTI features a single peptide folded in β-trefoil manner, with the molecular …

The complex world of plant protease inhibitors: Insights into a Kunitz-type cysteine protease inhibitor of Arabidopsis thaliana

S Rustgi, E Boex-Fontvieille, C Reinbothe… - … & integrative biology, 2018 - Taylor & Francis
Plants have evolved an intricate regulatory network of proteases and corresponding
protease inhibitors (PI), which operate in various biological pathways and serve diverse …

TcTI, a Kunitz-type trypsin inhibitor from cocoa associated with defense against pathogens

M do Amaral, ACO Freitas, AS Santos… - Scientific Reports, 2022 - nature.com
Protease inhibitors (PIs) are important biotechnological tools of interest in agriculture.
Usually they are the first proteins to be activated in plant-induced resistance against …

[HTML][HTML] Purification, primary structure and potential functions of a novel lectin from Bauhinia forficata seeds

MCC Silva, LA Santana, R Mentele, RS Ferreira… - Process …, 2012 - Elsevier
A new lectin, BfL, was purified from Bauhinia forficata seeds by ammonium sulfate
fractionation, DEAE-Sephadex ion exchange chromatography, Sepharose-4B and chitin …

MnASI1 Mediates Resistance to Botrytis cinerea in Mulberry (Morus notabilis)

D Wang, N Gong, C Liu, S Li, Z Guo, G Wang… - International Journal of …, 2022 - mdpi.com
Six α-amylase/subtilisin inhibitor genes (MnASIs) were identified from mulberry (Morus
notabilis). In this study, bioinformatics and expression pattern analysis of six MnASIs were …