Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

New perspectives in diabetic neuropathy

SA Eid, AE Rumora, B Beirowski, DL Bennett, J Hur… - Neuron, 2023 - cell.com
Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

Research progress on the hypoglycemic activity and mechanisms of natural polysaccharides

H Xue, Z Hao, Y Gao, X Cai, J Tang, X Liao… - International Journal of …, 2023 - Elsevier
The incidence of diabetes, as a metabolic disease characterized by high blood sugar levels,
is increasing every year. The predominantly western medicine treatment is associated with …

Genetics of diabetes-associated microvascular complications

V Lyssenko, A Vaag - Diabetologia, 2023 - Springer
Diabetes is associated with excess morbidity and mortality due to both micro-and
macrovascular complications, as well as a range of non-classical comorbidities. Diabetes …

TRPA1 antagonists for pain relief

A Koivisto, N Jalava, M Rantanen, H Chapman… - TRP Channels as …, 2024 - Elsevier
The topic of this chapter, transient receptor potential ankyrin 1 (TRPA1), is a calcium-
permeable nonselective cation channel that is a member of the TRP family expressed on …

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Y Xu, Q Hu, Z Wei, Y Ou, Y Cao, H Zhou… - Biomaterials …, 2023 - spj.science.org
Diabetic ulcers (DUs) are one of the most serious complications of diabetes mellitus. The
application of a functional dressing is a crucial step in DU treatment and is associated with …

Clinical and biomechanical effectiveness of foot‐ankle exercise programs and weight‐bearing activity in people with diabetes and neuropathy: a systematic review …

JJ Van Netten, ICN Sacco, L Lavery… - Diabetes/metabolism …, 2024 - Wiley Online Library
Background Most interventions to prevent foot ulcers in people with diabetes do not seek to
reverse the foot abnormalities that led to the ulcer. Foot‐ankle exercise programs target …

[HTML][HTML] Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment

J Zhu, Z Hu, Y Luo, Y Liu, W Luo, X Du… - Frontiers in …, 2024 - frontiersin.org
Diabetic peripheral neuropathy (DPN) refers to the development of peripheral nerve
dysfunction in patients with diabetes when other causes are excluded. Diabetic distal …

Single‐cell RNA‐seq uncovers novel metabolic functions of Schwann cells beyond myelination

SA Eid, M Noureldein, B Kim, LM Hinder… - Journal of …, 2023 - Wiley Online Library
Schwann cells (SCs) support peripheral nerves under homeostatic conditions, independent
of myelination, and contribute to damage in prediabetic peripheral neuropathy (PN). Here …

Diabetic neuropathy: pathogenesis and evolving principles of management

B Zaino, R Goel, S Devaragudi, A Prakash… - Disease-a-Month, 2023 - Elsevier
The global rise of prediabetes and diabetes has spawned an epidemic of complications
associated with these conditions. Neuropathy is the most common consequence, with distal …